| Postprandial nutrient partitioning but not energy expenditure is modified in growing rats during adaptation to a high-protein diet. | |
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MedLine Citation:
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PMID: 20335631 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been suggested that high-protein (HP) diets may favor weight management by lowering energy intake and reducing body fat. Whether these effects result from changes in energy metabolism remains unclear. We measured the adaptation of energy metabolism components during 2 wk of HP feeding. Fifty male Wistar rats were switched from a control diet to an HP diet (14 and 55% of protein, respectively) for 1, 3, 6, or 14 d. Energy expenditure (EE) and substrate oxidation were measured by indirect calorimetry in feed-deprived rats and after consumption of a test meal. EE components, including the thermic effect of feeding and activity, were not modified during adaptation to an HP diet. Nutrient oxidation in feed-deprived rats was not affected by HP feeding, except for an early increase in protein oxidation. After 1 d, the postprandial inhibition of lipid oxidation (Lox) was blunted, carbohydrate (CHO) oxidation decreased by one-half, and urea clearance decreased by 66%. Thereafter, CHO oxidation gradually rose, resulting in a null CHO balance. Lox and urea clearance recovered after 3 d of adaptation to an HP diet, while protein oxidation reached a plateau. The postprandial oxidation of CHO counterbalanced the amount of ingested CHO as soon as 3 d, leading to a null postprandial CHO balance. We conclude that the inhibition of de novo lipogenesis from dietary CHO, but not EE and Lox, may participate in limiting the adiposity induced by HP feeding. The transient changes occurring during the period of adaptation to the diet highlight that the duration of the diet is critical in HP diet studies. |
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Authors:
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Magdalena Stepien; Claire Gaudichon; Dalila Azzout-Marniche; Gilles Fromentin; Daniel Tom?; Patrick Even |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-24 |
Journal Detail:
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Title: The Journal of nutrition Volume: 140 ISSN: 1541-6100 ISO Abbreviation: J. Nutr. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-21 Completed Date: 2010-05-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 939-45 Citation Subset: IM |
Affiliation:
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INRA, AgroParisTech, UMR914 Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity
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physiology* Animals Body Temperature Regulation Calorimetry, Indirect Dietary Carbohydrates / administration & dosage, metabolism* Dietary Fats / administration & dosage, metabolism* Dietary Proteins / administration & dosage, metabolism* Energy Metabolism* Lipogenesis / physiology* Male Obesity / metabolism* Oxidation-Reduction Postprandial Period Rats Rats, Wistar Urea / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; 57-13-6/Urea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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