Document Detail

Postprandial C-peptide to glucose ratio as a predictor of β-cell function and its usefulness for staged management of type 2 diabetes.
MedLine Citation:
PMID:  25411619     Owner:  NLM     Status:  Publisher    
AIMS/INTRODUCTION: Type 2 diabetes is characterized by progressive deterioration of β-cell function. Recently, it was suggested that the C-peptide-to-glucose ratio after oral glucose ingestion is a better predictor of β-cell mass than that during fasting. We investigated whether postprandial C-peptide-to-glucose ratio (PCGR) reflects β-cell function, and its clinical application for management of type 2 diabetes.
MATERIALS AND METHODS: We carried out a two-step retrospective study of 919 Korean participants with type 2 diabetes. In the first step, we evaluated the correlation of PCGR level with various markers for β-cell function in newly diagnosed and drug-naïve patients after a mixed meal test. In the second step, participants with well-controlled diabetes (glycated hemoglobin <7%) were divided into four groups according to treatment modality (group I: insulin, group II: sulfonylurea and/or dipeptityl peptidase IV inhibitor, group III: metformin and/or thiazolidinedione and group IV: diet and exercise group).
RESULTS: In the first step, PCGR was significantly correlated with various insulin secretory indices. Furthermore, PCGR showed better correlation with glycemic indices than homeostatic model assessment of β-cell function (HOMA-β). In the second step, the PCGR value significantly increased according to the following order: group I, II, III, and IV after adjusting for age, sex, body mass index and duration of diabetes. The cut-off values of PCGR for separating each group were 1.457, 2.870 and 3.790, respectively (P < 0.001).
CONCLUSIONS: We suggest that PCGR might be a useful marker for β-cell function and an ancillary parameter in the choice of antidiabetic medication in type 2 diabetes.
Eun Young Lee; Sena Hwang; Seo Hee Lee; Yong-Ho Lee; A Ra Choi; Youngki Lee; Byung-Wan Lee; Eun Seok Kang; Chul Woo Ahn; Bong Soo Cha; Hyun Chul Lee
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-12
Journal Detail:
Title:  Journal of diabetes investigation     Volume:  5     ISSN:  2040-1116     ISO Abbreviation:  J Diabetes Investig     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-11-20     Completed Date:  -     Revised Date:  2014-11-21    
Medline Journal Info:
Nlm Unique ID:  101520702     Medline TA:  J Diabetes Investig     Country:  -    
Other Details:
Languages:  ENG     Pagination:  517-524     Citation Subset:  -    
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