| Postponing or eliminating red blood cell transfusions of very low birth weight neonates by obtaining all baseline laboratory blood tests from otherwise discarded fetal blood in the placenta. | |
| | |
MedLine Citation:
|
PMID: 20723166 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: Safely reducing the proportion of very low birth weight neonates (<1500 g) that receive a red blood cell (RBC) transfusion would be an advance in transfusion practice. STUDY DESIGN AND METHODS: We performed a prospective, single-centered, case-control, feasibility analysis, preparatory to designing a definitive trial. Specifically, we sought to determine whether we could obtain all baseline neonatal intensive care unit blood tests from the placenta, after placental delivery, thereby initially drawing no blood from the neonate. RESULTS: Ten cases where all baseline blood tests were drawn from the placenta, and 10 controls where all tests were drawn from the neonate, were closely matched for birth weight, gestational age, sex, and race. Early cord clamping was used for all 20. Over the first 18 hours the hemoglobin increased in nine cases versus two controls (p = 0.005). During the first 72 hours one case versus five controls qualified for and received an RBC transfusion. In the first week the cases received four transfusions and the controls received 16 (p = 0.02). None of the cases had an intraventricular hemorrhage (IVH) but four of the controls had a Grade 1 and two had a Grade 3 (p = 0.01). CONCLUSION: We speculate that this method is feasible and generally postpones the first RBC transfusion until beyond the period of peak vulnerability to IVH. |
| | |
Authors:
|
Robert D Christensen; Diane K Lambert; Vickie L Baer; Dianne P Montgomery; Cindy K Barney; David M Coulter; Sarah Ilstrup; Sterling T Bennett |
Related Documents
:
|
12169936 - Massive transfusion exceeding 50 units of blood products in trauma patients. 12415516 - Meta-analysis of randomized controlled trials investigating the risk of postoperative i... 9466086 - A risk-benefit assessment of aprotinin in cardiac surgical procedures. 19590316 - Transfusion and pneumonia in the trauma intensive care unit: an examination of the temp... 18200826 - Short-term effect of the hmg-coa reductase inhibitor rosuvastatin on erythrocyte nitric... 19867686 - The oxygen content of the blood in lobar pneumonia. |
Publication Detail:
|
Type: Journal Article Date: 2010-08-16 |
Journal Detail:
|
Title: Transfusion Volume: 51 ISSN: 1537-2995 ISO Abbreviation: Transfusion Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-02-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0417360 Medline TA: Transfusion Country: United States |
Other Details:
|
Languages: eng Pagination: 253-8 Citation Subset: IM |
Copyright Information:
|
© 2010 American Association of Blood Banks. |
Affiliation:
|
From the Department of Women and Newborns, Intermountain Healthcare, Salt Lake City, Utah; the McKay-Dee Hospital Center, Ogden, Utah; the Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah; and the Intermountain Medical Center, Murray, Utah. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Weak D and DEL alleles detected by routine SNaPshot genotyping: identification of four novel RHD all...
Next Document: Factors affecting banking quality of umbilical cord blood for transplantation.