| Postpneumonectomy alveolar growth does not normalize hemodynamic and mechanical function. | |
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MedLine Citation:
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PMID: 10444603 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immature foxhounds underwent 55% lung resection by right pneumonectomy (n = 5) or thoracotomy without pneumonectomy (Sham, n = 6) at 2 mo of age. Cardiopulmonary function was measured during treadmill exercise on reaching maturity 1 yr later. In pneumonectomized animals compared with Sham animals, maximal oxygen uptake, ventilatory response, and cardiac output during exercise were normal. Arterial and mixed venous blood gases and arteriovenous oxygen extraction during exercise were also normal. Mean pulmonary arterial pressure and resistance were elevated at a given cardiac output. Dynamic ventilatory power requirement was also significantly elevated at a given minute ventilation. These long-term hemodynamic and mechanical abnormalities are in direct contrast to the normal pulmonary gas exchange during exercise in these same pneumonectomized animals reported elsewhere (S. Takeda, C. C. W. Hsia, E. Wagner, M. Ramanathan, A. S. Estrera, and E. R. Weibel. J. Appl. Physiol. 86: 1301-1310, 1999). Functional compensation was superior in animals pneumonectomized as puppies than as adults. These data indicate a limited structural response of conducting airways and extra-alveolar pulmonary blood vessels to pneumonectomy and suggest the development of other sources of adaptation such as those involving the heart and respiratory muscles. |
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Authors:
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S I Takeda; M Ramanathan; A S Estrera; C C Hsia |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 87 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1999 Aug |
Date Detail:
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Created Date: 1999-09-08 Completed Date: 1999-09-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 491-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235-9034, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Airway Resistance Animals Blood Pressure Cardiac Output Dogs Exercise Test Hemodynamics / physiology* Male Physical Conditioning, Animal Pneumonectomy* Pulmonary Alveoli / physiology* Pulmonary Artery / physiology Pulmonary Ventilation Respiratory Mechanics / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01-HL-40070/HL/NHLBI NIH HHS; R01-HL-45716/HL/NHLBI NIH HHS; R01-HL-54060/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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