Document Detail


Postparturitional testosterone surge in male offspring of rats stressed and/or fed ethanol during late pregnancy.
MedLine Citation:
PMID:  11855908     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Male offspring of rats exposed to restraint stress and/or alcohol during late pregnancy show aberrant patterns of sexual behavior masculinization and defeminization that vary as a function of treatment. The impact of these treatments on the postparturitional testosterone (T) surge that contributes to sexual behavior differentiation was investigated. Plasma T was measured using radioimmunoassay in individual males sampled on day 21 of gestation within 10 min of cesarean delivery or 1, 2, or 4 h thereafter. Neonatal T in the group exposed only to stress did not differ from that in the control group. T was lower than control levels at birth in both alcohol groups. The magnitude of the T surge that occurred during the first hour of birth in the control group was diminished by 50% in both alcohol groups, whose T pattern was very similar. There was no common alteration in postparturitional T associated with the increased lordotic behavior potential that males in all three treatment groups typically share, nor were there idiosyncratic endocrine abnormalities linked to the very different male copulatory pattern each exhibits. Exposure to an abnormal T milieu during fetal as well as neonatal ontogeny may underlie the etiology of the different sexual behavior patterns exhibited by males exposed to stress and/or alcohol. Possible unique effects each treatment exerts on perinatal plasma T and it's aromatization to estradiol in hypothalamic targets are discussed.
Authors:
O Byron Ward; Ingeborg L Ward; John H Denning; Jeffrey A French; Shelton E Hendricks
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hormones and behavior     Volume:  41     ISSN:  0018-506X     ISO Abbreviation:  Horm Behav     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-07     Completed Date:  2002-05-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0217764     Medline TA:  Horm Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  229-35     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science (USA).
Affiliation:
Department of Psychology, Villanova University, Villanova, Pennsylvania 19085, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / physiology
Behavior, Animal / drug effects
Diet
Ethanol / pharmacology*
Female
Male
Pregnancy
Pregnancy, Animal / physiology*
Rats
Rats, Sprague-Dawley
Restraint, Physical
Stress, Psychological / blood,  physiopathology*
Testosterone / blood*
Grant Support
ID/Acronym/Agency:
5-R01-HD-04688/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
58-22-0/Testosterone; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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