| Postpartum "psychosis" in mild argininosuccinate synthetase deficiency. | |
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MedLine Citation:
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PMID: 15863597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Urea cycle disorders are relatively rare but well-established causes of postpartum coma and death. Such clinical presentations have been reported previously in ornithine transcarbamylase and carbamyl phosphate synthetase deficiencies. CASE: We describe a woman, without prior symptoms of metabolic disease, who presented with hyperammonemia and psychiatric symptoms in the postpartum period. Initial diagnoses included acute fatty liver of pregnancy and postpartum psychosis. She was later found to have argininosuccinate synthetase deficiency after further metabolic investigations. Rare heterozygous mutations in the argininosuccinate synthetase gene were identified. CONCLUSION: Urea cycle disorders may present initially with postpartum psychiatric symptoms and may represent an underrecognized cause of "postpartum psychosis." We recommend obtaining metabolic studies in women with neurologic or severe psychiatric symptoms in the postpartum period. |
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Authors:
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Gregory M Enns; William E O'Brien; Keiko Kobayashi; Haruhide Shinzawa; Joan E Pellegrino |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 105 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-05-02 Completed Date: 2005-06-30 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 1244-6 Citation Subset: AIM; IM |
Affiliation:
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Division of Medical Genetics, Department of Pediatrics, Stanford University, Stanford, California 94305-5208, USA. greg.enns@stanford.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Argininosuccinate Synthase / deficiency* Depression, Postpartum / diagnosis*, enzymology, therapy Diagnosis, Differential Female Follow-Up Studies Humans Metabolic Diseases / diagnosis*, therapy Postpartum Period Pregnancy Puerperal Disorders / diagnosis, enzymology, therapy Risk Factors Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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EC 6.3.4.5/Argininosuccinate Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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