Document Detail


Postpartum hemorrhage in the developed world: whither misoprostol?
MedLine Citation:
PMID:  22901709     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We reviewed the literature to determine the optimal medical treatment of postpartum hemorrhage caused by uterine atony. Of the available uterotonics, only misoprostol and oxytocin have undergone rigorous comparative study. Of the 2, misoprostol is inferior: 2 recent well-done randomized trials with enrollment of more than 2200 patients demonstrated that, in situations in which prophylactic oxytocin has already been utilized, additional oxytocin is as effective as or better than misoprostol in terminating bleeding, while avoiding the high rate of fever (22-58%) associated with misoprostol. The second of these trials demonstrated that misoprostol does not augment the effect of oxytocin. We conclude that in settings in which oxytocin is available, oxytocin should remain the mainstay of both prophylaxis and first-line treatment of postpartum hemorrhage caused by uterine atony. In the developed world, the use of misoprostol for postpartum hemorrhage should be infrequent.
Authors:
Karen J Gibbins; Catherine M Albright; Dwight J Rouse
Related Documents :
22570339 - Effects of psychological interventions for patients with systemic lupus erythematosus: ...
22918259 - Trauma scoring systems.
22713409 - The pathophysiology and pharmacological treatment of huntington disease.
16595029 - Assessing drug risks and benefits: lessons from postmenopausal hormone therapy studies.
22439669 - Rasagiline: a review of its use in the treatment of idiopathic parkinson's disease.
8605459 - Blinding and exclusions after allocation in randomised controlled trials: survey of pub...
23680979 - Scoring of human acute pancreatitis: state of the art.
22868539 - Migraine diagnosis and pathophysiology.
9690699 - A double-blind, placebo-controlled, crossover trial of an antiandrogen in the treatment...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-1
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  -     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, Women and Infants Hospital of Rhode Island, Brown University, Providence, RI 02905.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Why the term neonatal encephalopathy should be preferred over neonatal hypoxic-ischemic encephalopat...
Next Document:  Defining uterine tachysystole: how much is too much?