Document Detail


Postpartum acquired hemophilia (factor VIII inhibitors): a case report and review of the literature.
MedLine Citation:
PMID:  11128909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pathologic inhibitors of blood coagulation as a cause of postpartum acquired hemostatic failure are rare. Since 1937, 96 cases of postpartum factor VIII (FVIII) inhibitors, including the current case, have been reported. Suspicion for the diagnosis of this condition is often low. We report a case of postpartum FVIII inhibitor formation in a 24-year-old woman who developed intermittent postpartum bleeding that resulted from the inhibitors she formed to FVIII. A unique form of therapy was used in treatment of her disorder. She did not respond to conventional surgical or medical management of her bleeding until Autoplex T (Baxter Healthcare, Glendale, CA), an activated prothrombin complex concentrate (aPCC) was used. The literature concerning acquired hemophilia is reviewed, and new therapeutic medical advances are emphasized.
Authors:
S A Shobeiri; E C West; M J Kahn; T E Nolan
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Obstetrical & gynecological survey     Volume:  55     ISSN:  0029-7828     ISO Abbreviation:  Obstet Gynecol Surv     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-20     Completed Date:  2001-02-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401007     Medline TA:  Obstet Gynecol Surv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  729-37     Citation Subset:  IM    
Affiliation:
Louisiana State University Health Sciences Center, Department of Obstetrics and Gynecology, New Orleans 70112, USA. shobeiri@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Coagulation Factors / therapeutic use
Factor VIII / antagonists & inhibitors*
Female
Hemophilia A / drug therapy,  etiology*,  immunology,  physiopathology
Humans
Partial Thromboplastin Time
Postpartum Hemorrhage / diagnosis,  etiology*,  physiopathology,  therapy
Pregnancy
Chemical
Reg. No./Substance:
0/Blood Coagulation Factors; 37224-63-8/prothrombin complex concentrates; 9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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