| Postpartum acquired hemophilia (factor VIII inhibitors): a case report and review of the literature. | |
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MedLine Citation:
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PMID: 11128909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pathologic inhibitors of blood coagulation as a cause of postpartum acquired hemostatic failure are rare. Since 1937, 96 cases of postpartum factor VIII (FVIII) inhibitors, including the current case, have been reported. Suspicion for the diagnosis of this condition is often low. We report a case of postpartum FVIII inhibitor formation in a 24-year-old woman who developed intermittent postpartum bleeding that resulted from the inhibitors she formed to FVIII. A unique form of therapy was used in treatment of her disorder. She did not respond to conventional surgical or medical management of her bleeding until Autoplex T (Baxter Healthcare, Glendale, CA), an activated prothrombin complex concentrate (aPCC) was used. The literature concerning acquired hemophilia is reviewed, and new therapeutic medical advances are emphasized. |
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Authors:
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S A Shobeiri; E C West; M J Kahn; T E Nolan |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Obstetrical & gynecological survey Volume: 55 ISSN: 0029-7828 ISO Abbreviation: Obstet Gynecol Surv Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2000-12-20 Completed Date: 2001-02-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0401007 Medline TA: Obstet Gynecol Surv Country: United States |
Other Details:
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Languages: eng Pagination: 729-37 Citation Subset: IM |
Affiliation:
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Louisiana State University Health Sciences Center, Department of Obstetrics and Gynecology, New Orleans 70112, USA. shobeiri@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Coagulation Factors / therapeutic use Factor VIII / antagonists & inhibitors* Female Hemophilia A / drug therapy, etiology*, immunology, physiopathology Humans Partial Thromboplastin Time Postpartum Hemorrhage / diagnosis, etiology*, physiopathology, therapy Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Blood Coagulation Factors; 37224-63-8/prothrombin complex concentrates; 9001-27-8/Factor VIII |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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