Document Detail


Postpartum-acquired haemophilia A: a description of three cases and literature review.
MedLine Citation:
PMID:  19521237     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Postpartum-acquired haemophilia A is a rare but potentially severe complication of pregnancy. Although the natural history of the disease is usually benign, with a high percentage of spontaneous remissions and a low mortality, its quick recognition is important to control bleeding episodes. The therapeutic strategies in these patients are the treatment of acute bleeding episodes and the long-term eradication of the autoantibody. We report three different cases of postpartum-acquired haemophilia demonstrating the broad heterogeneity of the clinical presentation and of therapeutic necessity of this condition. Finally, we present a review of the literature on the current therapeutic management of this haemorrhagic disorder.
Authors:
Rita C Santoro; Simona Prejan??
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  20     ISSN:  1473-5733     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-13     Completed Date:  2009-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  461-5     Citation Subset:  IM    
Affiliation:
Haemophilia Center, Haemostasis and Thrombosis Service, Oncology and Haematology Department, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy. ritasant@interfree.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia / etiology,  therapy
Autoantibodies / biosynthesis,  immunology*
Autoimmune Diseases / drug therapy,  etiology*,  immunology
Blood Transfusion
Combined Modality Therapy
Curettage
Ecchymosis / drug therapy,  etiology
Factor VIII / immunology*
Factor VIIa / therapeutic use
Female
Hematoma / drug therapy,  etiology,  therapy
Hemophilia A / diagnosis,  drug therapy,  etiology*,  immunology
Humans
Immunoglobulins, Intravenous / therapeutic use
Infant, Newborn
Male
Prednisone / therapeutic use
Pregnancy
Puerperal Disorders / diagnosis,  drug therapy,  etiology*,  immunology,  therapy
Recombinant Proteins / therapeutic use
Uterine Hemorrhage / drug therapy,  etiology,  therapy
Young Adult
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/F8 protein, human; 0/Immunoglobulins, Intravenous; 0/Recombinant Proteins; 0/recombinant FVIIa; 53-03-2/Prednisone; 9001-27-8/Factor VIII; EC 3.4.21.21/Factor VIIa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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