| Postpartum-acquired haemophilia A: a description of three cases and literature review. | |
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MedLine Citation:
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PMID: 19521237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postpartum-acquired haemophilia A is a rare but potentially severe complication of pregnancy. Although the natural history of the disease is usually benign, with a high percentage of spontaneous remissions and a low mortality, its quick recognition is important to control bleeding episodes. The therapeutic strategies in these patients are the treatment of acute bleeding episodes and the long-term eradication of the autoantibody. We report three different cases of postpartum-acquired haemophilia demonstrating the broad heterogeneity of the clinical presentation and of therapeutic necessity of this condition. Finally, we present a review of the literature on the current therapeutic management of this haemorrhagic disorder. |
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Authors:
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Rita C Santoro; Simona Prejan?? |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Volume: 20 ISSN: 1473-5733 ISO Abbreviation: Blood Coagul. Fibrinolysis Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-13 Completed Date: 2009-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102551 Medline TA: Blood Coagul Fibrinolysis Country: England |
Other Details:
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Languages: eng Pagination: 461-5 Citation Subset: IM |
Affiliation:
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Haemophilia Center, Haemostasis and Thrombosis Service, Oncology and Haematology Department, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy. ritasant@interfree.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia / etiology, therapy Autoantibodies / biosynthesis, immunology* Autoimmune Diseases / drug therapy, etiology*, immunology Blood Transfusion Combined Modality Therapy Curettage Ecchymosis / drug therapy, etiology Factor VIII / immunology* Factor VIIa / therapeutic use Female Hematoma / drug therapy, etiology, therapy Hemophilia A / diagnosis, drug therapy, etiology*, immunology Humans Immunoglobulins, Intravenous / therapeutic use Infant, Newborn Male Prednisone / therapeutic use Pregnancy Puerperal Disorders / diagnosis, drug therapy, etiology*, immunology, therapy Recombinant Proteins / therapeutic use Uterine Hemorrhage / drug therapy, etiology, therapy Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/F8 protein, human; 0/Immunoglobulins, Intravenous; 0/Recombinant Proteins; 0/recombinant FVIIa; 53-03-2/Prednisone; 9001-27-8/Factor VIII; EC 3.4.21.21/Factor VIIa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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