Document Detail


Postpartum acquired factor VIII inhibitors.
MedLine Citation:
PMID:  16868941     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of factor VIII autoantibodies is a rare but severe complication of pregnancy. Although the natural history of postpartum acquired hemophilia A is usually benign, with a high percentage of spontaneous remissions and a low mortality, its quick recognition is important to control bleeding episodes. Based on an analysis of the literature, this review presents the current knowledge on the pathogenesis, diagnosis, epidemiology, natural history, clinical manifestations, and therapeutic management of postpartum acquired hemophilia A.
Authors:
Massimo Franchini
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of hematology     Volume:  81     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-14     Completed Date:  2007-10-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  768-73     Citation Subset:  IM    
Affiliation:
Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy. mfranchini@univr.it
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MeSH Terms
Descriptor/Qualifier:
Autoantibodies / blood
Coagulants / therapeutic use
Factor VIII / immunology*,  therapeutic use
Female
Hemophilia A / drug therapy,  epidemiology,  immunology*
Humans
Postpartum Hemorrhage / drug therapy,  epidemiology,  immunology*
Pregnancy
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Coagulants; 9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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