| Postoperative oral amiodarone as prophylaxis against atrial fibrillation after coronary artery surgery. | |
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MedLine Citation:
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PMID: 12407614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the prophylactic effect of postoperative oral amiodarone on the incidence and severity of atrial fibrillation (AF) after coronary artery surgery. DESIGN: Prospective, randomized, blinded, controlled study. SETTING: University hospital. PARTICIPANTS: Patients who had coronary artery surgery (n = 200). INTERVENTIONS: Patients in group 1 (n = 100) received oral amiodarone, 15 mg/kg, 4 hours after arrival in the intensive care unit, followed by 7 mg/kg/d until hospital discharge. Patients in group 2 (n = 100) received placebo. MEASUREMENTS AND MAIN RESULTS: Incidence, duration, and recurrence of new episodes of AF and maximal ventricular rate response were recorded from day 0 until hospital discharge. Side effects related to amiodarone and complications induced by new-onset AF were noted. The incidence of new-onset AF (12% v 25%) and maximal ventricular rate response (120 +/- 21 beats/min v 135 +/- 24 beats/min) were significantly lower in the amiodarone group. There were no side effects related to the administration of amiodarone. The incidence of complications induced by AF was comparable between the 2 groups. CONCLUSION: Postoperative prophylactic oral amiodarone after coronary artery surgery is safe and effective in reducing the incidence of new-onset AF and maximal ventricular rate response. |
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Authors:
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Alexandre Yazigi; Pielly Rahbani; Hicham Abou Zeid; Samia Madi-Jebara; Fadia Haddad; Gemma Hayek |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of cardiothoracic and vascular anesthesia Volume: 16 ISSN: 1053-0770 ISO Abbreviation: J. Cardiothorac. Vasc. Anesth. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-10-30 Completed Date: 2003-01-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9110208 Medline TA: J Cardiothorac Vasc Anesth Country: United States |
Other Details:
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Languages: eng Pagination: 603-6 Citation Subset: IM |
Copyright Information:
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Copyright 2002, Elsevier Science (USA). All rights reserved. |
Affiliation:
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Department of Anesthesia and Intensive Care, Hotel-Dieu de France Hospital, Saint-Joseph University, Beirut, Lebanon. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adrenergic beta-Antagonists / therapeutic use Adult Aged Amiodarone / administration & dosage, therapeutic use* Anti-Arrhythmia Agents / therapeutic use* Atrial Fibrillation / prevention & control* Coronary Artery Bypass / adverse effects* Double-Blind Method Female Humans Male Middle Aged Postoperative Complications / prevention & control* Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Anti-Arrhythmia Agents; 1951-25-3/Amiodarone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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