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Postoperative neurocognitive function and microembolus detection in patients undergoing neck dissection: a pilot study.
MedLine Citation:
PMID:  20394111     Owner:  NLM     Status:  In-Process    
BACKGROUND AND OBJECTIVE: Patients undergoing oncologic neck dissection may have many of the risk factors for carotid artery stenosis, thus predisposing them to perioperative cerebral ischaemic events. The present study was designed to investigate development of postoperative neurocognitive dysfunction in these patients. METHODS: Twenty-six patients were assessed the day before surgery and 48 h and 12 months after surgery using a comprehensive neuropsychological test battery. Cognitive performance was compared with a matched control group to account for the practise effect associated with repeated testing. Doppler ultrasonography was used to detect intraoperative cerebral microembolism. S100beta protein values were evaluated before and immediately after anaesthesia. RESULTS: On the second postoperative day, 26.9% of patients undergoing neck dissection had postoperative neurocognitive deficit (POCD), defined as a total deficit score of 2SD worse than the mean performance in the control group. Microemboli were found only in the neck dissection group. S100beta levels were significantly higher after neck dissection (Wilcoxon signed ranked test: P<0.001). After 12 months, the incidence of POCD was similar in both groups. CONCLUSION: POCD was detectable only after neck dissection in the early postoperative period accompanied by increased incidence of microembolism and protein S100beta levels, but not 12 months after surgery.
J?rn Leiendecker; Jan H?cker; Patrick Meybohm; Axel Fudickar; Berthold Bein
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  27     ISSN:  1365-2346     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  417-24     Citation Subset:  IM    
Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
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