Document Detail

Postoperative long-term maintenance therapy with oral contraceptives after gonadotropin-releasing hormone analog treatment in women with ovarian endometrioma.
MedLine Citation:
PMID:  18976968     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: The goal of this preliminary study was to assess the effect of cyclic monophasic oral contraceptives (OCs) as a postoperative long-term maintenance therapy (median 33.2 months) to suppress recurrence of endometrioma after conservative ovarian surgery followed by gonadotropin-releasing hormone (GnRH) analog treatment. DESIGN: Retrospective clinical study (Canadian Task Force classification II-2). SETTING: Adolescent and premarital clinic in a university hospital. PATIENTS: The study was performed on 51 patients who underwent conservative surgery for endometrioma followed by GnRH analog treatment for 6 months. INTERVENTIONS: We used cyclic monophasic OCs as maintenance therapy after surgical and medical treatment with GnRH analog for 6 months. MEASUREMENTS AND MAIN RESULTS: Cyclic monophasic OCs were offered to young patients (n=51, age=24.1+/-2.8 years) who did not want to conceive immediately, to prevent the recurrence of endometrioma after conservative surgery with 6 cycles of postoperative GnRH analog treatment. During the long-term follow-up period (median 41.2; range 19-94 months), no recurrences of the endometrioma occurred in the current OC users. One patient showed a recurrence of endometrioma at 12 months after the discontinuation of the OCs. The median duration of OC administration was 33.20 months (range 12-86). In addition, 4 of 10 patients became pregnant within 12 months of discontinuing the long-term OC therapy. CONCLUSION: Postoperative long-term maintenance therapy with OCs can effectively suppress endometrioma recurrence in adolescent and young patients.
Hyun-Jung Park; Young-Ah Koo; Byung-Koo Yoon; Dooseok Choi
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Publication Detail:
Type:  Journal Article     Date:  2008-10-30
Journal Detail:
Title:  Journal of minimally invasive gynecology     Volume:  16     ISSN:  1553-4650     ISO Abbreviation:  -     Publication Date:    2009 Jan-Feb
Date Detail:
Created Date:  2008-12-26     Completed Date:  2009-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101235322     Medline TA:  J Minim Invasive Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  34-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul, Korea.
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MeSH Terms
Antineoplastic Agents, Hormonal / therapeutic use*
Contraceptives, Oral, Combined / administration & dosage*
Desogestrel / administration & dosage
Drug Administration Schedule
Endometriosis / drug therapy*,  surgery
Ethinyl Estradiol / administration & dosage
Leuprolide / therapeutic use*
Ovarian Diseases / drug therapy*,  surgery
Prospective Studies
Recurrence / prevention & control
Retrospective Studies
Young Adult
Reg. No./Substance:
0/Antineoplastic Agents, Hormonal; 0/Contraceptives, Oral, Combined; 53714-56-0/Leuprolide; 54024-22-5/Desogestrel; 57-63-6/Ethinyl Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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