| Postoperative long-term maintenance therapy with oral contraceptives after gonadotropin-releasing hormone analog treatment in women with ovarian endometrioma. | |
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MedLine Citation:
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PMID: 18976968 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY OBJECTIVE: The goal of this preliminary study was to assess the effect of cyclic monophasic oral contraceptives (OCs) as a postoperative long-term maintenance therapy (median 33.2 months) to suppress recurrence of endometrioma after conservative ovarian surgery followed by gonadotropin-releasing hormone (GnRH) analog treatment. DESIGN: Retrospective clinical study (Canadian Task Force classification II-2). SETTING: Adolescent and premarital clinic in a university hospital. PATIENTS: The study was performed on 51 patients who underwent conservative surgery for endometrioma followed by GnRH analog treatment for 6 months. INTERVENTIONS: We used cyclic monophasic OCs as maintenance therapy after surgical and medical treatment with GnRH analog for 6 months. MEASUREMENTS AND MAIN RESULTS: Cyclic monophasic OCs were offered to young patients (n=51, age=24.1+/-2.8 years) who did not want to conceive immediately, to prevent the recurrence of endometrioma after conservative surgery with 6 cycles of postoperative GnRH analog treatment. During the long-term follow-up period (median 41.2; range 19-94 months), no recurrences of the endometrioma occurred in the current OC users. One patient showed a recurrence of endometrioma at 12 months after the discontinuation of the OCs. The median duration of OC administration was 33.20 months (range 12-86). In addition, 4 of 10 patients became pregnant within 12 months of discontinuing the long-term OC therapy. CONCLUSION: Postoperative long-term maintenance therapy with OCs can effectively suppress endometrioma recurrence in adolescent and young patients. |
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Authors:
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Hyun-Jung Park; Young-Ah Koo; Byung-Koo Yoon; Dooseok Choi |
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Publication Detail:
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Type: Journal Article Date: 2008-10-30 |
Journal Detail:
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Title: Journal of minimally invasive gynecology Volume: 16 ISSN: 1553-4650 ISO Abbreviation: - Publication Date: 2009 Jan-Feb |
Date Detail:
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Created Date: 2008-12-26 Completed Date: 2009-03-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101235322 Medline TA: J Minim Invasive Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 34-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Agents, Hormonal / therapeutic use* Contraceptives, Oral, Combined / administration & dosage* Desogestrel / administration & dosage Drug Administration Schedule Endometriosis / drug therapy*, surgery Ethinyl Estradiol / administration & dosage Female Humans Leuprolide / therapeutic use* Ovarian Diseases / drug therapy*, surgery Prospective Studies Recurrence / prevention & control Retrospective Studies Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Hormonal; 0/Contraceptives, Oral, Combined; 53714-56-0/Leuprolide; 54024-22-5/Desogestrel; 57-63-6/Ethinyl Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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