| Postoperative irradiation combined with chemotherapy for high-risk rectal cancer patients. | |
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MedLine Citation:
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PMID: 21590203 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In a prospective open-study we evaluated the combination of radiation therapy and adjuvant 5-FU plus levamisole in controlling Modified Astler-Coller (MAC) B2 or C rectal cancer following a curative-intended surgery. Sixty-four consecutive rectal cancer patients were treated by adjuvant radiation therapy (Linac 8 MV, 50-50.4 Gy to an isocentric pelvis brick volume in 5 fractions per week each of 1.8-2 Gy), and 12 monthly courses of 5-fluorouracil (375 mg/m(2)/day for 5 consecutive days) plus levamisole (50 mg t.i.d. for 3 days). Within a median follow-up period of 36 months, 19 patients (29.6%) experienced relapses. The 3-year-DFS of MAC B2 patients was 82%, compared with 60% in MAC C. Early radiation treatment was not associated with a higher proportion of relapses, while late radiation therapy initiation was associated with a significantly higher proportion of relapses. Early radiation therapy, not later than following the 2nd to 4th course of chemotherapy, is associated with the more acceptable proportion of relapses. |
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Authors:
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O Merimsky; F Kovner; S Chaitchik; M Inbar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Oncology reports Volume: 4 ISSN: 1021-335X ISO Abbreviation: Oncol. Rep. Publication Date: 1997 Sep-Oct |
Date Detail:
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Created Date: 2011-05-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9422756 Medline TA: Oncol Rep Country: Greece |
Other Details:
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Languages: eng Pagination: 1093-7 Citation Subset: - |
Affiliation:
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TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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