Document Detail

Postoperative inflammatory reaction and atrial fibrillation: simple correlation or causation?
MedLine Citation:
PMID:  19559266     Owner:  NLM     Status:  MEDLINE    
Atrial fibrillation after cardiac operations is a source of morbidity and resource consumption. This systematic review of literature analyzes the current evidence on its pathophysiologic link with the systemic inflammatory response elicited by surgery and cardiopulmonary bypass. Meta-analysis of randomized studies on the effect of off-pump surgery or statin pre-treatment on the incidence of atrial fibrillation was performed. The concept of inflammation as a pathophysiologic determinant of postoperative atrial fibrillation is supported by the literature. The modulation of post-cardiopulmonary bypass systemic inflammation will probably represent a major therapeutic goal in the prevention of postoperative atrial fibrillation. Statins seem to be the most promising pharmacological strategy.
Amedeo Anselmi; Gianfederico Possati; Mario Gaudino
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  88     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-29     Completed Date:  2009-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  326-33     Citation Subset:  AIM; IM    
Division of Cardiac Surgery, Catholic University, Rome, Italy.
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MeSH Terms
Atrial Fibrillation / etiology*,  physiopathology,  prevention & control
C-Reactive Protein / metabolism*
Cardiopulmonary Bypass / adverse effects,  methods
Coronary Artery Bypass, Off-Pump / adverse effects*,  methods
Coronary Disease / diagnosis,  mortality
Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage*
Inflammation Mediators / analysis
Oxidative Stress / physiology*
Postoperative Complications / prevention & control
Predictive Value of Tests
Preoperative Care / methods
Randomized Controlled Trials as Topic
Risk Assessment
Survival Analysis
Treatment Outcome
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Inflammation Mediators; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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