Document Detail

Postoperative infections in colonic surgery after enteral bacitracin-neomycin-clindamycin or parenteral mezlocillin-oxacillin prophylaxis.
MedLine Citation:
PMID:  6208248     Owner:  NLM     Status:  MEDLINE    
In a prospective randomized, blind trial, three groups of patients undergoing elective colonic surgery were compared for frequency of surgical wound infection, intra-operative wound contamination and other postoperative infections. All patients allotted to the three groups received whole gut irrigation (101 balanced salt solution) by gastric tube on the evening before surgery and were treated as follows. Group A: no antibiotics; Group B: neomycin (1 g/l) + bacitracin (50,000 IU/l) + clindamycin (900 mg/l), contained in the last 31 of irrigation fluid; Group C: mezlocillin (4 g) + oxacillin (2 g) intravenously (iv) at induction of anaesthesia, followed by two identical doses at 8 and 16 h. The rate of postoperative wound infection was highest in A (38 per cent) and much lower in B (3.3 per cent, P less than 0.002) and C (6.9 per cent, P less than 0.004). The difference between B and C was statistically not significant. In A a correlation was established between the degree of wound contamination and the occurrence of wound infection. Intra-operative wound contamination was lowest in B (30 per cent), equal in A (58.1 per cent) and B (55.2 per cent). Other infections were least frequent in group C (four of 29 patients), but were not significantly different to groups B (six of 30) and A (nine of 31). It is concluded that antibiotics together with an effective mechanical preparation considerably reduce the rate of wound infection in colonic surgery.
R Schiessel; I Huk; M Starlinger; M Wunderlich; M Rotter; G Wewalka; M Schemper
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of hospital infection     Volume:  5     ISSN:  0195-6701     ISO Abbreviation:  J. Hosp. Infect.     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-12-18     Completed Date:  1984-12-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8007166     Medline TA:  J Hosp Infect     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  289-97     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / administration & dosage*
Bacitracin / therapeutic use
Clindamycin / therapeutic use
Clinical Trials as Topic
Colonic Diseases / surgery*
Drug Therapy, Combination
Infusions, Parenteral
Mezlocillin / therapeutic use
Middle Aged
Neomycin / therapeutic use
Oxacillin / therapeutic use
Surgical Wound Infection / prevention & control*
Reg. No./Substance:
0/Anti-Bacterial Agents; 1404-04-2/Neomycin; 1405-87-4/Bacitracin; 18323-44-9/Clindamycin; 51481-65-3/Mezlocillin; 66-79-5/Oxacillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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