Document Detail

Postoperative hypoxaemia: continuous extradural infusion of bupivacaine and morphine vs patient-controlled analgesia with intravenous morphine.
MedLine Citation:
PMID:  9771300     Owner:  NLM     Status:  MEDLINE    
We carried out a randomized prospective study in 60 patients who had undergone major abdominal surgery for cancer. For postoperative pain control, 30 patients received continuous extradural infusion of 0.125% bupivacaine 12.5 mg h-1 and morphine 0.25 mg h-1 (EXI group) and 30 received patient-controlled analgesia (PCA) with intravenous morphine (1 mg bolus, 5-min lock-out and maximum dose 20 mg 4h-1). Both groups had general anaesthesia. The two groups were compared for postoperative pain scores, satisfaction, sedation and oxygen saturation. Oxygen saturation was recorded continuously the night before surgery and for two consecutive postoperative nights. Episodes of moderate desaturation (90% > SpO2 85%) were more frequent in the EXI group than in the PCA group (P < 0.05). Pain scores were lower in the EXI group compared with the PCA group at rest and while coughing (P < 0.05). No significant difference was found for patient sedation and satisfaction.
C Motamed; A Spencer; F Farhat; J L Bourgain; P Lasser; C Jayr
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  80     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-10-21     Completed Date:  1998-10-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  742-7     Citation Subset:  IM    
Département de Chirurgie, Institut Gustave Roussy, Villejuif, France.
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MeSH Terms
Abdominal Neoplasms / surgery
Analgesia, Epidural / adverse effects*
Analgesia, Patient-Controlled / adverse effects*
Analgesics, Opioid / adverse effects
Anesthetics, Local / adverse effects
Anoxia / chemically induced*
Bupivacaine / adverse effects
Infusions, Intravenous
Middle Aged
Morphine / adverse effects
Pain, Postoperative / drug therapy*
Patient Satisfaction
Prospective Studies
Reg. No./Substance:
0/Analgesics, Opioid; 0/Anesthetics, Local; 2180-92-9/Bupivacaine; 57-27-2/Morphine
Comment In:
Br J Anaesth. 1998 Nov;81(5):826-7   [PMID:  10193303 ]
Erratum In:
Br J Anaesth. 1998 Nov;81(5):826-7   [PMID:  10193303 ]

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