| Postoperative erythroderma with change of HLA phenotypes from heterozygotes to homozygotes: a report of two cases. | |
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MedLine Citation:
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PMID: 1826657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fatal "postoperative erythroderma" (POE) developed in 2 patients treated with liver lobectomy and the transfusion of fresh blood. Their clinical features and skin-histological findings were indicative of acute graft-versus-host disease (GVHD). The HLA phenotypes of circulating lymphocytes of the 2 patients were heterozygous but became homozygous late in the clinical course and were identical with those of the blood donors. One of the patient's haplotypes was identical with the donor's homozygous haplotype. These findings suggest the mechanism of development of POE in apparently immunocompetent patients. The donor's T lymphocytes are histocompatible with the patient's tissues, are not rejected, and become engrafted. The patient's tissues are not histocompatible with the donor's, so that GVHD develops. |
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Authors:
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K Ito; M Fujita; M Norioka; H Yoshida; S Arii; J Tanaka; T Tobe; M Kakuyama; E Maruya; H Saji |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: European journal of haematology Volume: 46 ISSN: 0902-4441 ISO Abbreviation: Eur. J. Haematol. Publication Date: 1991 Apr |
Date Detail:
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Created Date: 1991-05-20 Completed Date: 1991-05-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8703985 Medline TA: Eur J Haematol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 217-22 Citation Subset: IM |
Affiliation:
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Department of Transfusion Medicine, Kyoto University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Donors Blood Transfusion* Dermatitis, Exfoliative / immunology* Graft vs Host Disease / immunology* HLA Antigens / analysis, immunology* Heterozygote Homozygote Humans Immunophenotyping Lymphocytes / immunology* Male Middle Aged Phenotype* Postoperative Complications* |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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