| Postoperative endocrine function in patients with surgically treated thyrotoxicosis. | |
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MedLine Citation:
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PMID: 15054736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Endocrine function after surgery for thyrotoxicosis is difficult to predict. The operative morbidity and long-term thyroid function of patients surgically treated for thyrotoxicosis is presented, and factors postulated to affect long-term function are correlated with outcome. METHODS: The clinical records of 289 consecutive patients who underwent surgery for thyrotoxicosis were reviewed. Indications for surgery, intraoperative findings, postoperative complications, and endocrine status 1, 2, and 5 years after surgery were analyzed. Sex, age, duration of medical treatment, weight of thyroid removed and preserved, and antimicrosomal/antithyroglobulin antibody status were correlated with outcome 5 years after surgery. RESULTS: The incidence of permanent recurrent laryngeal nerve injury and hypocalcemia were 0.7% and 1.7%. The cumulative hypothyroid and hyperthyroid rates for the first, second, and fifth postoperative years were 13.8% and 3.5%, 14.5% and 4.8%, and 15.6% and 8.0%. All the prognostic variables analyzed did not achieve a significant correlation with outcome at 5 years by univariate and multivariate age- and sex-adjusted relative risk. CONCLUSIONS: Failure from hypothyroidism develops early; recurrent hyperthyroidism increases with the number of years of follow-up. Patients undergoing subtotal thyroidectomy warrant long-term follow-up because of the inability to accurately predict postoperative function with consistently reliable prognostic factors. |
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Authors:
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Ranjiv Sivanandan; Lay Guat Ng; Lay Wai Khin; Teck Hock Dennis Lim; Khee Chee Soo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Head & neck Volume: 26 ISSN: 1043-3074 ISO Abbreviation: Head Neck Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-03-31 Completed Date: 2004-07-29 Revised Date: 2006-10-05 |
Medline Journal Info:
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Nlm Unique ID: 8902541 Medline TA: Head Neck Country: United States |
Other Details:
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Languages: eng Pagination: 331-7 Citation Subset: IM |
Copyright Information:
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Copyright 2004 Wiley Periodicals, Inc. |
Affiliation:
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Department of Surgery, Singapore General Hospital, Singapore. ranjiv@ohns.stanford.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Goiter / diagnosis Graves Disease / diagnosis Humans Hyperthyroidism / etiology* Hypocalcemia / etiology* Hypothyroidism / etiology* Laryngeal Nerves / injuries Male Multivariate Analysis Organ Size Postoperative Complications* Prognosis Recurrence Thyroid Gland / pathology Thyroidectomy / methods Thyrotoxicosis / surgery* Time Factors Treatment Outcome |
| Comments/Corrections | |
Comment In:
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Head Neck. 2005 Nov;27(11):1014; author reply 1014-5
[PMID:
16136582
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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