| Postoperative concurrent chronomodulated 5-fluorouracil/leucovorin infusion and pelvic radiotherapy for squamous cell carcinoma of the ovary arising from mature cystic teratoma. | |
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MedLine Citation:
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PMID: 11737476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary squamous cell carcinoma (SCC) of the ovary arising from mature cystic teratoma (MCT) is rare. Survival is very poor. Although different postoperative treatments have been tried, none appears to have influenced outcomes. A 44-year-old patient with FIGO stage IIB SCC of the ovary arising in MCT had exploratory laparotomy and left salpingo-oophorectomy, leaving macroscopic residual pelvic disease. Postoperative treatment consisted of a continuous concurrent chronomodulated infusion of 5-fluorouracil 150 mg/m2/day and leucovorin 10 mg/m2/day with 5 weeks of pelvic radiotherapy. Three years after initial surgery, she remains disease and complication free. Given this patient's unusually long disease-free survival and the efficacy of concurrent chemotherapy and radiotherapy in other SCCs, the concurrent circadian treatment approach used for this patient should be explored in other cases of SCC of the ovary. |
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Authors:
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V T Do; G M Thomas; G A Bjarnason |
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Publication Detail:
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Type: Case Reports; Letter |
Journal Detail:
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Title: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society Volume: 11 ISSN: 1048-891X ISO Abbreviation: Int. J. Gynecol. Cancer Publication Date: 2001 Sep-Oct |
Date Detail:
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Created Date: 2001-12-12 Completed Date: 2002-02-01 Revised Date: 2006-11-07 |
Medline Journal Info:
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Nlm Unique ID: 9111626 Medline TA: Int J Gynecol Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 418-21 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Carcinoma, Squamous Cell / drug therapy*, radiotherapy, secondary, surgery Combined Modality Therapy Female Fluorouracil / administration & dosage Humans Leucovorin / administration & dosage Ovarian Neoplasms / drug therapy*, pathology, radiotherapy, surgery Ovariectomy Pelvic Neoplasms / drug therapy*, radiotherapy, secondary, surgery Postoperative Care Teratoma / drug therapy*, pathology, radiotherapy, surgery |
| Chemical | |
Reg. No./Substance:
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51-21-8/Fluorouracil; 58-05-9/Leucovorin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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