| Postoperative cognitive dysfunction after noncardiac surgery: effects of metabolic syndrome. | |
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MedLine Citation:
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PMID: 21516370 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Vascular risk factors, including metabolic syndrome, are known to contribute to the development of cognitive dysfunction. We tested the hypothesis that patients with metabolic syndrome are more likely to develop cognitive dysfunction after noncardiac surgery. METHODS: Age- and education-balanced patients (n = 60) undergoing elective noncardiac surgery with and without metabolic syndrome and 30 nonsurgical controls were enrolled. Recent verbal and nonverbal memory and executive functions were assessed using a psychometric test battery before and 1 month after noncardiac surgery or at a 1-month interval in nonsurgical controls. RESULTS: Neurocognitive scores under baseline conditions were similar in surgical patients with versus without metabolic syndrome in all examined cognitive modalities (recent nonverbal and verbal memory, executive functions). Pronounced reductions in tests of verbal memory (delayed story recall, immediate and delayed word list recall) and executive function (backward digit span) were observed in patients with versus without metabolic syndrome after surgery. Overall cognitive performance after surgery was also significantly (P = 0.03) more impaired in patients with versus without metabolic syndrome. The prevalence rate of POCD wasdifferent in the studied groups (17/30 [corrected] and 8/30 in patientswith versus without metabolic syndrome; P < 0.02). CONCLUSIONS: The results indicate that cognitive functions were more profoundly impaired in patients with metabolic syndrome undergoing noncardiac surgery compared with their healthier counterparts. |
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Authors:
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Judith A Hudetz; Kathleen M Patterson; Oludara Amole; Aaron V Riley; Paul S Pagel |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-04-23 |
Journal Detail:
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Title: Journal of anesthesia Volume: 25 ISSN: 1438-8359 ISO Abbreviation: J Anesth Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-09 Completed Date: 2011-09-30 Revised Date: 2011-11-30 |
Medline Journal Info:
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Nlm Unique ID: 8905667 Medline TA: J Anesth Country: Japan |
Other Details:
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Languages: eng Pagination: 337-44 Citation Subset: IM |
Affiliation:
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Division of Anesthesiology, Clement J. Zablocki Veterans Administration Medical Center, 5000 W. National Avenue, Milwaukee, WI 53295, USA. judith.hudetz@va.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cognition / physiology Cognition Disorders / etiology*, psychology* Depression / psychology Executive Function Female Humans Male Memory / physiology Metabolic Syndrome X / complications*, psychology* Middle Aged Neuropsychological Tests Postoperative Complications / psychology* Risk Factors Sample Size Surgical Procedures, Operative |
| Comments/Corrections | |
Comment In:
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J Anesth. 2011 Oct;25(5):796; author reply 797
[PMID:
21894566
]
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Erratum In:
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J Anesth. 2011 Oct;25(5):798 J Anesth. 2011 Aug;25(4):640 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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