Document Detail

Postoperative changes in serum cytokines profile and nitric oxide levels in patients with cystic echinococcosis.
MedLine Citation:
PMID:  16218215     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to examine serum cytokines and nitric oxide (NO) levels in patients with cystic echinococcosis (CE). 28 patients with CE were studied and all underwent surgery. Serum levels of tumour necrosis factor-alpha (TNF-alpha), interleukin IL-1beta, receptor of soluble IL-2R (sIL-2R), IL-6, IL-8, nitrate/nitrite, and C-reactive protein (CRP) were determined before and after induction of treatment. Data were compared with those obtained from 28 healthy volunteers. IL-6 was elevated in all CE patients (100%). IL-8 was increased in 11/28 (39.3%). Increased levels of IL-2R and TNF-alpha were found in a limited number of them particularly those showing cysts in the central area of the liver (5/28, 6/28). IL-1beta level was not elevated in any patient except in secondary severe CE. CRP and nitrate/nitrite levels were also increased. A positive correlation between CRP and IL-6 (r = 0.74; p < 0.001) was found confirming the link between inflammation due to CE and activation of monocytes. All patients completely recovered and the levels of the studied parameters reverted to normal levels except one patient in whom severe recurrent disease occurred two years after the first operation. These results suggest that there are different immunoregulatory events and cytokines response during CE and may be in part related to slight monocytosis and in part to Th2 activation. IL-6, NO and CRP were unambiguously involved in the host parasite interaction and therefore may be useful markers in monitoring CE management and evaluating surgical stress.
M Refik; N Mehmet; R Durmaz
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Parasite (Paris, France)     Volume:  12     ISSN:  1252-607X     ISO Abbreviation:  Parasite     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-10-12     Completed Date:  2005-11-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9437094     Medline TA:  Parasite     Country:  France    
Other Details:
Languages:  eng     Pagination:  265-9     Citation Subset:  IM    
Department of Clinical Microbiology, Faculty of Medicine, Inonu University, Malatya, Turkey.
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MeSH Terms
C-Reactive Protein / metabolism
Cytokines / blood*
Echinococcosis / blood*,  surgery*
Interleukins / blood
Nitric Oxide / blood*
Postoperative Period
Reference Values
Reg. No./Substance:
0/Cytokines; 0/Interleukins; 10102-43-9/Nitric Oxide; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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