Document Detail

Postoperative changes in hemostasis analyzed by the serial determination of fibrinopeptides and D-dimer.
MedLine Citation:
PMID:  2674499     Owner:  NLM     Status:  MEDLINE    
In order to elucidate the postoperative changes in hemostasis, three molecular markers; fibrinopeptide A (FPA), fibrinopeptide B beta 15-42 (B beta 15-42) and D-dimer, were serially determined in 27 gastric resections (group A), 27 hepatic resections (group B) and 4 probe laparotomies (group C). Unexpectedly, a postoperative hypercoagulable state was transient and of a low magnitude, as determined by the obtained value of FPA. On the other hand, a significant fibrinolysis (an elevation of B beta 15-42) was observed immediately after surgery which continued for over 10 days. The early phase of fibrinolysis, up until the 3rd postoperative day, is likely to be primary fibrinolysis, as it was not accompanied by the formation of D-dimer, which results from the digestion of fibrin by plasmin. The late phase, however, is considered to be secondary fibrinolysis, as D-dimer was elevated during this phase. Despite the different surgical procedures, these changes were basically similar between the patients who underwent gastric resections and those who underwent liver resections. The postoperative changes in hemostasis as presented herein may therefore be the general physiological response, at least against abdominal surgery.
J Kang; J Kambayashi; M Sakon; T Tsujinaka; T Mori
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Japanese journal of surgery     Volume:  19     ISSN:  0047-1909     ISO Abbreviation:  Jpn J Surg     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-10-23     Completed Date:  1989-10-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1302176     Medline TA:  Jpn J Surg     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  262-8     Citation Subset:  IM    
Second Department of Surgery, Osaka University Medical School, Japan.
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MeSH Terms
Abdomen / surgery*
Blood Coagulation
Fibrin Fibrinogen Degradation Products*
Fibrinogen / metabolism*
Fibrinopeptide A / metabolism*
Fibrinopeptide B / metabolism*
Middle Aged
Peptide Fragments / metabolism*
Postoperative Period
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/Peptide Fragments; 0/fibrinopeptide Bbeta (15-42); 25422-31-5/Fibrinopeptide A; 36204-23-6/Fibrinopeptide B; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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