| Postoperative bleeding in retired racing greyhounds. | |
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MedLine Citation:
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PMID: 18466249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Some retired racing Greyhounds (RRG) that undergo surgery bleed excessively. Hypothesis: Greyhounds that bleed excessively will have one or more preoperative hemostatic abnormalities that can be used to predict the risk and severity of postoperative bleeding. ANIMALS: Eighty-eight RRG undergoing ovariohysterectomy or castration. METHODS: All dogs were evaluated preoperatively with a physical exam, CBC, platelet count, OSPT, APTT, platelet function with PFA-100(a); fibrinogen, d-dimer, plasminogen (Plmg), antiplasmin (AP), antithrombin (AT), and vWF concentration (vWF:Ag); vWF collagen binding assay (vWF:CBA), and Factor XIII assay. Assays were repeated in the dogs that bled, and in an age- and sex-matched control group of RRG. RESULTS: Twenty-six percent of the dogs had bleeding 36-48 hours after surgery. AP (P <.0001) and AT concentration (P= .007) were significantly lower, and vWF:CBA (P= .0284) was higher preoperatively in the dogs with excessive hemorrhage. A lower platelet count (P= .001) and hematocrit (P= .002), shorter OSPT (P= .0002) and higher plasma fibrinogen (P <.0001), and AP (P= .001) concentration were detected at the time of bleeding compared with preoperative values in the dogs that bleed excessively. The same findings were observed postoperatively for the control group, except for the decrease in hematocrit. CONCLUSIONS AND CLINICAL IMPORTANCE: The results indicate that this excessive postoperative bleeding is not attributable to a primary or secondary hemostatic defect, but could result from altered fibrinolysis. |
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Authors:
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A Lara-García; C G Couto; M C Iazbik; M B Brooks |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-02 |
Journal Detail:
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Title: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine Volume: 22 ISSN: 0891-6640 ISO Abbreviation: J. Vet. Intern. Med. Publication Date: 2008 May-Jun |
Date Detail:
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Created Date: 2008-05-16 Completed Date: 2008-09-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708660 Medline TA: J Vet Intern Med Country: United States |
Other Details:
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Languages: eng Pagination: 525-33 Citation Subset: IM |
Affiliation:
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Department of Veterinary Clinical Sciences and Veterinary Teaching Hospital, The Ohio State University, Columbus, Ohio, USA. lara-garcia.3@osu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Case-Control Studies Dog Diseases / epidemiology, genetics* Dogs Female Genetic Predisposition to Disease Hysterectomy / adverse effects, veterinary Male Orchiectomy / adverse effects, veterinary Ovariectomy / adverse effects, veterinary Partial Thromboplastin Time / veterinary Platelet Count / veterinary Postoperative Hemorrhage / epidemiology, genetics, veterinary* Preoperative Care / veterinary Prevalence Prospective Studies Prothrombin Time / veterinary Risk Factors Time Factors von Willebrand Factor / metabolism |
| Chemical | |
Reg. No./Substance:
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0/von Willebrand Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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