| Postoperative administration of landiolol hydrochloride for patients with supraventricular arrhythmia: the efficacy of sustained intravenous infusion at a low dose. | |
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MedLine Citation:
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PMID: 19666952 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to investigate the efficacy of landiolol hydrochloride, a short-acting beta(1) blocker, by initiating its administration at a low dose (5 microg kg(-1) min(-1)) in patients with postoperative supraventricular arrhythmia. The efficacy of landiolol was evaluated in 38 patients who, after developing postoperative atrial flutter or fibrillation, with sinus tachycardia and two patients who had a history of paroxysmal atrial fibrillation with frequent atrial extrasystole. The heart rate and blood pressure before and 2 h after the administration of landiolol were compared. A return to the sinus rhythm from supraventricular arrhythmia was noted in 89%. The heart rate was reduced from 137+/-26 bpm (before landiolol administration) to 93+/-18 bpm (2 h after the start of the medication, P<0.01). As an agent to correct an arrhythmic condition, landiolol successfully raised the systolic blood pressure from 108+/-24 mmHg (before medication) to 120+/-19 mmHg (2 h after the medication was started, P<0.05). Continuous intravenous infusion of landiolol at a low dose was found to be effective for postoperative supraventricular arrhythmia. |
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Authors:
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Seiichiro Wariishi; Koichi Yamashita; Hideaki Nishimori; Takashi Fukutomi; Masaki Yamamoto; Geethalakshmi Radhakrishnan; Shiro Sasaguri |
Publication Detail:
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Type: Journal Article Date: 2009-08-10 |
Journal Detail:
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Title: Interactive cardiovascular and thoracic surgery Volume: 9 ISSN: 1569-9285 ISO Abbreviation: Interact Cardiovasc Thorac Surg Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-15 Completed Date: 2009-12-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101158399 Medline TA: Interact Cardiovasc Thorac Surg Country: England |
Other Details:
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Languages: eng Pagination: 811-3 Citation Subset: IM |
Affiliation:
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Department of Surgery II, Kochi University, Kohasu, Nankoku, Kochi, Japan. wari@kochi-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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administration & dosage* Adult Aged Aged, 80 and over Anti-Arrhythmia Agents / administration & dosage* Arrhythmias, Cardiac / drug therapy*, etiology, physiopathology Atrial Fibrillation / drug therapy, etiology Atrial Flutter / drug therapy, etiology Atrial Premature Complexes / drug therapy, etiology Blood Pressure / drug effects Drug Administration Schedule Female Heart Rate / drug effects Humans Infusions, Intravenous Male Middle Aged Morpholines / administration & dosage* Postoperative Care Receptors, Adrenergic, beta-1 / antagonists & inhibitors* Surgical Procedures, Operative / adverse effects* Tachycardia, Sinus / drug therapy, etiology Time Factors Treatment Outcome Urea / administration & dosage, analogs & derivatives* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Anti-Arrhythmia Agents; 0/Morpholines; 0/Receptors, Adrenergic, beta-1; 133242-30-5/landiolol; 57-13-6/Urea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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