Document Detail

Postoperative adjuvant radiation therapy in the treatment of primary head and neck mucosal melanomas.
MedLine Citation:
PMID:  18984969     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: The role of postoperative radiotherapy (PORT) in head and neck mucosal melanomas (HNMM) is not yet clearly defined. The aim of this study is to report the 21-year experience of the Brazilian National Cancer Institute in such treatment. METHODS: From January 1983 to December 2003, 31 patients with confirmed histological diagnosis of HNMM underwent treatment at the Brazilian National Cancer Institute. Of these, 20 received radical treatment with surgery alone (8 patients--group 1) or surgery and PORT (12 patients--group 2). RESULTS: Local control and the median time to local failure at 5 years were 75% and 14 months for group 1 and 83.5% and 40 months for group 2 (p = 0.06). The overall survival rates at 3 years were 37.5% for group 1 and 58% for group 2. At 5 years the survival rates were 25% for both groups (p = NS). When PORT was initiated within 60 days after surgery, there was a trend towards improvement in overall survival (p = 0.08). After univariate analysis, distant metastasis, location of primary disease and tobacco smoking were important prognostic factors. CONCLUSION: Early (<60 days) PORT for HNMM provides better local control with a longer disease-free survival.
Juliano P Nakashima; Célia M Viégas; Ana L Fassizoli; Marcelo Rodrigues; Leonardo A G Chamon; João H C Silva; Fernando L Dias; Carlos M Araújo
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Publication Detail:
Type:  Journal Article     Date:  2008-11-04
Journal Detail:
Title:  ORL; journal for oto-rhino-laryngology and its related specialties     Volume:  70     ISSN:  1423-0275     ISO Abbreviation:  ORL J. Otorhinolaryngol. Relat. Spec.     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-05     Completed Date:  2009-02-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0334721     Medline TA:  ORL J Otorhinolaryngol Relat Spec     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  344-51     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Department of Radiation Oncology, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.
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MeSH Terms
Aged, 80 and over
Cohort Studies
Disease-Free Survival
Dose-Response Relationship, Radiation
Follow-Up Studies
Head and Neck Neoplasms / mortality,  pathology,  radiotherapy,  surgery
Melanoma / mortality*,  pathology,  radiotherapy*,  surgery
Middle Aged
Mucous Membrane / pathology*,  radiation effects
Otorhinolaryngologic Neoplasms / mortality*,  pathology,  radiotherapy*,  surgery
Otorhinolaryngologic Surgical Procedures / methods
Postoperative Care / methods
Radiotherapy Dosage
Radiotherapy, Adjuvant
Radiotherapy, Conformal*
Retrospective Studies
Risk Assessment
Survival Analysis
Treatment Outcome
Young Adult

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