Document Detail

Postoperative Hungry Bone Syndrome in Patients with Secondary Hyperparathyroidism of Renal Origin.
MedLine Citation:
PMID:  22399154     Owner:  NLM     Status:  Publisher    
BACKGROUND: Hungry bone syndrome (HBS) is a postoperative condition of severe hypocalcemia that can be seen in patients who have undergone parathyroidectomy (PTX) for secondary hyperparathyroidism (2HPT) of renal origin. This study examines HBS in patients after PTX for 2HPT. METHODS: Prospectively collected data was retrospectively reviewed in patients who underwent PTX for 2HPT of renal origin at a single institution. HBS was defined as the need for additional days of hospitalization or readmission for intravenous calcium supplementation due to clinical symptoms of hypocalcemia, including tingling, muscle spasms, and bone pain and/or immediate postoperative low serum calcium ≤7.5 mg/dl. RESULTS: Of 79 patients who underwent PTX for 2HPT, 27.8% (n = 22) experienced HBS. Young age (≤45 years, p = 0.02) was the only preoperative variable that predicted HBS. Most patients developed HBS within 18 h after surgery and required a prolonged hospital stay (19/22) compared to those requiring hospital readmission within the first 7 days (3/22). Initial postoperative serum calcium levels within 18 h of surgery were significantly lower in those patients who developed HBS (7.1 vs. 8.3 mg/dl, p = 0.001), and those patients also had a greater absolute decrease in serum calcium (2.8 vs. 3.5 mg/dl, p = 0.04). CONCLUSION: HBS develops in a significant proportion of patients generally within the first 18 h after subtotal PTX for 2HPT. The only identifiable preoperative risk factor for HBS was young age. Additionally, low initial calcium levels and greater absolute decrease in serum calcium may help identify those patients that will develop HBS requiring judicious calcium supplementation.
Melanie Goldfarb; Stephan S Gondek; Susan M Lim; Josephina C Farra; Vania Nose; John I Lew
Related Documents :
3678744 - Duodenal bulb acidity in patients with duodenal ulcer.
8659214 - Transcutaneous oxygen tension in patients with and without pericapillary fibrin cuffs i...
15063384 - Smoking habits in patient's who have been treated for an oral cancer: validation of sel...
24625564 - Prevalence of stroke and the need for thromboprophylaxis in young patients with atrial ...
22305054 - Acute exacerbation of usual interstitial pneumonia after resection of lung cancer.
7887554 - Trimethoprim-sulfamethoxazole for the prevention of spontaneous bacterial peritonitis i...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-8
Journal Detail:
Title:  World journal of surgery     Volume:  -     ISSN:  1432-2323     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704052     Medline TA:  World J Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Endocrine Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Recurrent bone marrow aplasia secondary to nilotinib in a patient with chronic myeloid leukemia: A c...
Next Document:  A prospective evaluation of quick intraoperative parathyroid hormone assay at the time of skin closu...