Document Detail

Postoperative complications after glaucoma surgery for primary angle-closure glaucoma vs primary open-angle glaucoma.
MedLine Citation:
PMID:  21482857     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To investigate the incidence of postoperative complications arising in the first year after trabeculectomy and combined phacotrabeculectomy in eyes with primary angle-closure glaucoma (PACG) vs those with primary open-angle glaucoma (POAG).
METHODS: This was a retrospective study of all glaucoma operations done at a Singapore hospital from January 9, 2001, to December 30, 2004. The types of glaucoma surgery included trabeculectomy and phacotrabeculectomy, all with mitomycin C or fluorouracil. The incidences of postoperative complications and reoperations were analyzed. For those who underwent bilateral or repeated operations, only the first operated eye of each subject was included.
RESULTS: A total of 446 subjects with PACG (112 who underwent trabeculectomy and 334 who underwent phacotrabeculectomy) and 816 subjects with POAG (208 who underwent trabeculectomy and 608 who underwent phacotrabeculectomy) were analyzed. Postoperative complications occurred in 65 of 1262 eyes (5.2%) overall, with 27 eyes (8.4%) in the trabeculectomy group (PACG: 8.0%; 95% confidence interval [CI], 4.3%-14.6%; POAG: 8.7%; 95% CI, 5.5%-13.3%; P > .99) and 38 eyes (4.0%) in the phacotrabeculectomy group (PACG: 5.1%; 95% CI, 3.2%-8.0%; POAG: 3.5%; 95% CI, 2.3%-5.2%; P = .31). The rate of complications was significantly higher in the trabeculectomy group than the phacotrabeculectomy group overall (P = .003), but there was no significant difference between the POAG and PACG groups overall (POAG: 4.8%; 95% CI, 3.5%-6.5%; PACG: 5.8%; 95% CI, 4.0%-8.4%; P = .53). The commonest complication found was hypotony with overfiltration (23 cases [1.8%]), followed by bleb leak (11 cases [0.9%]). There was no significant difference in incidence of reoperations between POAG (2.7%; 95% CI, 1.8%-4.1%) and PACG (4.0%; 95% CI, 2.6%-6.3%) (P = .27).
CONCLUSION: The incidences of postoperative complications and reoperations in the first year after glaucoma surgery were similar for PACG and POAG.
Yar-Li Tan; Pei-Fang Tsou; Gavin S Tan; Shamira A Perera; Ching-Lin Ho; Tina T Wong; Tin Aung
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-04-11
Journal Detail:
Title:  Archives of ophthalmology     Volume:  129     ISSN:  1538-3601     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-09     Completed Date:  2011-09-29     Revised Date:  2012-04-17    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  987-92     Citation Subset:  AIM; IM    
Singapore National Eye Centre, Singapore.
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MeSH Terms
Fluorouracil / administration & dosage
Glaucoma, Angle-Closure / physiopathology,  surgery*
Glaucoma, Open-Angle / physiopathology,  surgery*
Intraocular Pressure / physiology
Middle Aged
Mitomycin / administration & dosage
Postoperative Complications*
Retrospective Studies
Risk Factors
Trabecular Meshwork / surgery*
Reg. No./Substance:
50-07-7/Mitomycin; 51-21-8/Fluorouracil
Comment In:
Arch Ophthalmol. 2012 Mar;130(3):402; author reply 402-3   [PMID:  22411677 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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