Document Detail

Postoperative 5-fluorouracil versus intraoperative mitomycin C in high-risk glaucoma filtering surgery: extended follow up.
MedLine Citation:
PMID:  12786769     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare the long-term efficacy and safety of postoperative subconjunctival 5-fluorouracil (5-FU) injections with that of intraoperative mitomycin C (MMC) in eyes at high risk for failure of trabeculectomy. METHODS: In a retrospective, non-randomized comparative trial, 36 eyes of 36 consecutive patients at high risk for failure of trabeculectomy underwent glaucoma filtering surgery with either postoperative subconjunctival 5-FU injections (19 eyes) or intraoperative application of MMC (17 eyes). Intraocular pressure, number of postoperative antiglaucoma medications, postoperative visual acuity, interventions, and complications were evaluated. RESULTS: Overall success (intraocular pressure </=21 mmHg) at 1 year was 73.6% in the 5-FU group and 82.3% in the MMC group. The cumulative 4-year success was 52.6% in the 5-FU group and 60.5% in the MMC group (P = 0.6). At 4-year follow up, mean +/- SD intraocular pressures were 17.58 +/- 4.01 mmHg in the 5-FU group and 13.33 +/- 3.36 mmHg in the MMC group (P = 0.01). There was no significant difference in the number of post-operative medications (P = 0.84), appearance of blebs (P = 0.20), final visual acuity (P = 1.00), and complications (P > 0.05) between the groups. CONCLUSIONS: These results suggest that both postoperative 5-FU injections and intraoperative MMC application have long-term success in high-risk patients. However, MMC results in a greater decrease in intraocular pressure than 5-FU.
Cengiz Akarsu; Merih Onol; Berati Hasanreisoglu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical & experimental ophthalmology     Volume:  31     ISSN:  1442-6404     ISO Abbreviation:  Clin. Experiment. Ophthalmol.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-05     Completed Date:  2003-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100896531     Medline TA:  Clin Experiment Ophthalmol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  199-205     Citation Subset:  IM    
Department of Ophthalmology, School of Medicine, University of Kirikkale, Kirikkale, Turkey.
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MeSH Terms
Filtering Surgery* / adverse effects
Fluorouracil / therapeutic use*
Glaucoma / surgery*
Intraocular Pressure / drug effects
Intraoperative Care*
Middle Aged
Mitomycin / therapeutic use*
Preoperative Care*
Retrospective Studies
Visual Acuity
Reg. No./Substance:
50-07-7/Mitomycin; 51-21-8/Fluorouracil

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