Document Detail

Postnatally acquired cytomegalovirus infection via breast milk: effects on hearing and development in preterm infants.
MedLine Citation:
PMID:  15071286     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In preterm infants there is a high risk of transmission of cytomegalovirus (CMV) via breast milk from seropositive mothers with reactivation of the virus during lactation. There is little information about the long term sequel of early postnatally acquired CMV infection in pre-term infants. This study aimed to investigate whether there was an increased frequency of impaired neurodevelopmental outcome and sensorineural hearing loss in preterm infants with postnatally acquired CMV infection through transmission by CMV-positive breast milk. METHODS: Twenty-two preterm infants [median birth weight, 1020 g (range, 600 to 1870 g); median gestational age, 27.6 weeks (range, 23.6 to 32 weeks] with early postnatally acquired CMV infection by breast-feeding (onset of viruria between Days 23 and 190 postnatally) were compared with 22 CMV-negative preterm infants individually matched for gestational age, birth weight, gender, intracranial hemorrhage and duration of ventilation. At 2 to 4.5 years of age, follow-up assessments were conducted consisting of neurologic examination, neurodevelopmental assessment and detailed audiologic tests. RESULTS: None of the children had sensorineural hearing loss. There was no difference between the groups with regard to neurologic, speech and language or motor development. CONCLUSION: The results of this study suggest that early postnatally acquired CMV infection via CMV-positive breast milk does not have a negative effect on neurodevelopment and hearing in this group of patients. Because we studied a small number of infants, further follow-up studies are warranted in preterm infants with early postnatally acquired CMV infection.
Brigitte Vollmer; Karin Seibold-Weiger; Christine Schmitz-Salue; Klaus Hamprecht; Rangmar Goelz; Ingeborg Krageloh-Mann; Christian P Speer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  23     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-08     Completed Date:  2004-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  322-7     Citation Subset:  IM    
Department of Pediatric Neurology, Children's Hospital, University of Tubingen, Tubingen, Germany.
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MeSH Terms
Age Distribution
Case-Control Studies
Child Development / physiology*
Child, Preschool
Cytomegalovirus Infections / diagnosis*,  transmission*
DNA, Viral / analysis
Follow-Up Studies
Hearing Disorders / epidemiology*,  etiology
Infant, Newborn
Infant, Premature*
Infectious Disease Transmission, Vertical
Milk, Human / virology*
Pregnancy Complications, Infectious / diagnosis
Prospective Studies
Reference Values
Risk Assessment
Reg. No./Substance:
0/DNA, Viral

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