| Postnatal variations in blood free and acylcarnitines. | |
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MedLine Citation:
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PMID: 21438006 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Alteration in concentrations of blood carnitine and its esters are diagnostic of a number of inherited metabolic disorders. Acylcarnitine (AC) profiles of newborns obtained from dried blood spots by tandem mass spectrometric analysis are being used for the diagnosis of these disorders. There are no data of the postnatal variations of free carnitine (FC) and AC in Indian neonates. Objectives: Evaluation of postnatal variations in free and AC levels in newborns. Methods: Blood FC and AC levels were evaluated in 2,727 healthy neonates of postnatal day 2-30 by electrospray ionization tandem mass spectrometry. Results: Blood C2, C5DC, C16, C16:1, C18, C18:1, C18:2, and C18:OH carnitineswere increased in groups A (aged 8-14 days) and B (aged 15-30 days), compared with the control group (aged 2-7 days), whereas C3, C4, C4OH, C6, C6DC, and C12 carnitines were increased only in group B. No sex-related differences were found except for C3DC, C4, and C5 carnitine concentrations, which were higher in female neonates. Conclusions: Our data can be used as a reference for the assessment of carnitine status in Indian newborns, hence reducing the risk of misdiagnosis of fatty acid oxidation disorders and organic acidemias during interpretation of the results of tandem mass spectrometry-based newborn screening. J. Clin. Lab. Anal. 25:126-129, 2011. © 2011 Wiley-Liss, Inc. |
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Authors:
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Tanima De; T P Kruthika-Vinod; Dindagur Nagaraja; Rita Christopher |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical laboratory analysis Volume: 25 ISSN: 1098-2825 ISO Abbreviation: J. Clin. Lab. Anal. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-03-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8801384 Medline TA: J Clin Lab Anal Country: United States |
Other Details:
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Languages: eng Pagination: 126-9 Citation Subset: IM |
Copyright Information:
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© 2011 Wiley-Liss, Inc. |
Affiliation:
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Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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