| Postnatal remodeling of the neural components of the epithelial-mesenchymal trophic unit in the proximal airways of infant rhesus monkeys exposed to ozone and allergen. | |
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MedLine Citation:
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PMID: 14761677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nerves and neuroendocrine cells located within the airway epithelium are ideally situated to sample a changing airway environment, to transmit that information to the central nervous system, and to promote trophic interactions between epithelial and mesenchymal cellular and acellular components. We tested the hypothesis that the environmental stresses of ozone (O(3)) and house dust mite allergen (HDMA) in atopic infant rhesus monkeys alter the distribution of airway nerves. Midlevel bronchi and bronchioles from 6-month-old infant monkeys that inhaled filtered air (FA), house dust mite allergen HDMA, O(3), or HDMA + O(3) for 11 episodes (5 days each, 0.5 ppm O(3), 8 h/day followed by 9 days recovery) were examined using immunohistochemistry for the presence of Protein gene product 9.5 (PGP 9.5), a nonspecific neural indicator, and calcitonin gene-related peptide (CGRP). Along the axial path between the sixth and the seventh intrapulmonary airway generations, there were small significant (P < 0.05) decrements in the density of epithelial nerves in monkeys exposed to HDMA or O(3), while in monkeys exposed to HDMA + O(3) there was a greater significant (P < 0.05) reduction in epithelial innervation. In animals exposed to O(3) or HDMA + O(3) there was a significant increase in the number of PGP 9.5 positive/CGRP negative cells that were anchored to the basal lamina and emitted projections in primarily the lateral plain and often intertwined with projections and cell bodies of other similar cells. We conclude that repeated cycles of acute injury and repair associated with the episodic pattern of ozone and allergen exposure alter the normal development of neural innervation of the epithelial compartment and the appearance of a new population of undefined PGP 9.5 positive cells within the epithelium. |
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Authors:
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Shawnessy D Larson; Edward S Schelegle; William F Walby; Laural J Gershwin; Michelle V Fanuccihi; Michael J Evans; Jesse P Joad; Brian K Tarkington; Dallas M Hyde; Charles G Plopper |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Toxicology and applied pharmacology Volume: 194 ISSN: 0041-008X ISO Abbreviation: Toxicol. Appl. Pharmacol. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-02-05 Completed Date: 2004-03-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0416575 Medline TA: Toxicol Appl Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 211-20 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California-Davis, 1 Shields Avenue, Davis, CA 95616, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Allergens
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toxicity* Animals Animals, Newborn / physiology* Dermatophagoides farinae / immunology Filtration Immunohistochemistry Macaca mulatta Microscopy, Confocal Neural Conduction / physiology Olfactory Mucosa / innervation, physiology* Oxidants, Photochemical / toxicity* Ozone / toxicity* |
| Grant Support | |
ID/Acronym/Agency:
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ES 00628/ES/NIEHS NIH HHS; ES 006791/ES/NIEHS NIH HHS; HL 07013/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Oxidants, Photochemical; 10028-15-6/Ozone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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