Document Detail

Postnatal penicillin prophylaxis of early-onset group B streptococcal infection in term newborns. A preliminary study.
MedLine Citation:
PMID:  17690745     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Early-onset group B Streptococcal disease (EOGBSD) is a serious but preventable neonatal infection. Maternal intrapartum antibiotic prophylaxis (IAP) does not prevent all cases of the disease. Management of asymptomatic neonates of GBS colonized mothers is problematic. AIMS: The objective of this prospective study was to determine whether administration of intramuscular penicillin at birth to a strictly defined group of term newborns of GBS colonized mothers is an effective and safe method to prevent EOGBSD. METHODS: A protocol for management of full-term infants born to GBS colonized mothers was created. Either an abnormality of blood count or presence of more than one obstetric risk factor were chosen as the indication criteria for administering postnatal antibiotic prophylaxis (PAP). RESULTS: The study sample consists of 250 newborns (11.5% of all term infants). PAP was administered in 39 cases. Indication criteria included leucocytosis in 37 cases, leucopenia in 1 case and obstetric risk factors in 1 case. There was no case of clinically manifest infection, and no case of sepsis either suspect or proven. CONCLUSIONS: The authors suggest that the strategy of selective PAP using penicillin, may be an effective and safe method in order to reduce morbidity and mortality from streptococcal infections. They recommend a combination of IAP and selective PAP.
Lucia Stillova; Zuzana Strechova; Katarina Matasova; Hana Kolarovszka; Kristina Bodova; Juraj Stilla; Mirko Zibolen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia     Volume:  151     ISSN:  1213-8118     ISO Abbreviation:  Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-08-10     Completed Date:  2008-04-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140142     Medline TA:  Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  79-83     Citation Subset:  IM    
Clinic of Neonatology, Jessenius Faculty of Medicine, Comenius University, Faculty Hospital of Martin, Martin, Slovakia.
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MeSH Terms
Antibiotic Prophylaxis*
Infant, Newborn
Injections, Intramuscular
Penicillins / therapeutic use*
Risk Factors
Streptococcal Infections / prevention & control*
Streptococcus agalactiae*
Reg. No./Substance:

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