Document Detail

Postnatal patterns of brain lipids in progeny of vitamin B-6 deficient rats before and after pyridoxine supplementation.
MedLine Citation:
PMID:  966066     Owner:  NLM     Status:  MEDLINE    
The influence of deficient and adequate maternal intakes of pyridoxine on lipid profiles in brains of progeny at 5, 10, 15, 25 and 50 days of age was studied. The effects of supplementing deficient dams at two different times with pyridoxine on the brain development of progeny were also examined. Three groups of weanling, female rats were fed diets deficient in pyridoxine (1.2 mg pyridoxine-HC1/kg diet) and another group received a control diet (30.0 mg pyridoxine-HC1/kg diet). One deficient group and the control group were fed their diets throughout growth, gestation and lactation. Two groups of dams were fed the deficient diet through growth, gestation and until 5 or 10 days postpartum when pyridoxine was supplemented by feeding the control diet. Body and brain weights were significantly lower in 15, 25 and 50 day-old progeny of deficient dams and deficient dams supplemented at 10 days postpartum. Cerebroside content at 15 days and ganglioside content at 15 and 25 days were significantly lower in brains of pups from unsupplemented deficient dams and deficient dams supplemented at 10 days postpartum. The postnatal development of cerebroside and ganglioside levels in brain was delayed or retarded in brain of pups from unsupplemented deficient dams. Supplementation of dams fed a low level of pyridoxine (1.2 mg/kg diet) with the vitamin beginning at 5 days postpartum reversed all observed effects of the low vitamin intake on brain lipids in progeny.
M R Thomas; A Kirksey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nutrition     Volume:  106     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1976-11-21     Completed Date:  1976-11-21     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1404-14     Citation Subset:  IM    
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MeSH Terms
Age Factors
Body Weight
Brain / anatomy & histology,  metabolism*
Cerebellum / metabolism
Cerebrosides / metabolism
Cholesterol / metabolism
Gangliosides / metabolism
Lipid Metabolism*
Organ Size
Phospholipids / metabolism
Pregnancy Complications / metabolism
Pyridoxine* / metabolism,  therapeutic use
Vitamin B 6 Deficiency / drug therapy,  metabolism*
Reg. No./Substance:
0/Cerebrosides; 0/Gangliosides; 0/Phospholipids; 57-88-5/Cholesterol; 65-23-6/Pyridoxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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