Document Detail

Postnatal ontogeny of gamma glutamyltranspeptidase activity of pancreas in essential fatty acid deficient rats treated with nitrosomethylurea.
MedLine Citation:
PMID:  1980815     Owner:  NLM     Status:  MEDLINE    
The effect of essential fatty acid deficiency and nitrosomethylurea treatment on postnatal levels of pancreatic gamma-glutamyltranspeptidase was studied. A significant increase of gamma-glutamyltranspeptidase activity and changes in fatty acid composition were observed in essential fatty acid deficient rats, from the 14th day of life on. Pancreatic gamma-glutamyltranspeptidase of nitrosomethylurea injected rats in essential fatty acid deficiency and controls was significantly diminished at the 30th day, with no significant differences in both nutritional conditions. The results indicated: 1. Concomitant changes in gamma-glutamyltranspeptidase activity and fatty acid composition of rat pancreas in essential fatty acid deficiency, 2. A significant reduction of pancreatic gamma-glutamyltranspeptidase activity following a single intraperitoneal injection of nitrosomethylurea at day one of life and 3. No interacting effects of essential fatty acid deficiency and nitrosomethylurea on gamma-glutamyltranspeptidase activity of rat pancreas.
M A Valentich; B Monis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemistry international     Volume:  22     ISSN:  0158-5231     ISO Abbreviation:  Biochem. Int.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1991-03-14     Completed Date:  1991-03-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100311     Medline TA:  Biochem Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  141-7     Citation Subset:  IM    
Instituto de Biología Celular, Córdoba University Medical School, Argentina.
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MeSH Terms
Animals, Newborn
Fatty Acids / analysis
Fatty Acids, Essential / deficiency*
Methylnitrosourea / pharmacology*
Pancreas / chemistry,  enzymology*
Rats, Inbred Strains
gamma-Glutamyltransferase / metabolism*
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Essential; 684-93-5/Methylnitrosourea; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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