Document Detail


Postnatal maturation of vagal respiratory reflexes in preterm and full-term lambs.
MedLine Citation:
PMID:  12547837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The postnatal development of ventilatory reflexes originating from bronchopulmonary receptors was assessed in preterm vs. full-term lambs. Ventilation and arterial pressure were repeatedly measured in 10 preterm (gestational age, 132 days) and 7 full-term lambs without sedation from day 1 to day 42. The Hering-Breuer inhibitory reflex (slowly adapting stretch receptors) was assessed by the increase in expiratory time during end-inspiratory occlusion. The pulmonary chemoreflex (C-fiber endings) was assessed by the initial apnea + bradycardia + systemic hypotension and the secondary tachypnea after capsaicin intravenous injection. Results show the following. 1) Premature birth did not modify the maturation of the Hering-Breuer reflex. 2) Whereas a classic pulmonary chemoreflex was observed in the very first hours of life in preterm lambs, the tachypneic component of this reflex was weaker than in full-term lambs on day 1. 3) Premature birth led to a reversed postnatal maturation of this tachypneic response (tendency to increase with postnatal age). Our findings suggest that premature birth in lambs modifies postnatal maturation of the pulmonary chemoreflex.
Authors:
Julie Arsenault; Francois Moreau-Bussiere; Philippe Reix; Theophile Niyonsenga; Jean-Paul Praud
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-01-24
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  94     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-04-07     Completed Date:  2003-11-26     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1978-86     Citation Subset:  IM    
Affiliation:
Respiratory Research Unit, Department of Public Health, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4, USA. Jp.Praud@USherbrooke.ca
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology
Animals
Animals, Newborn / physiology*
Blood Gas Analysis
Blood Pressure / drug effects,  physiology
Capsaicin / pharmacology
Heart Rate / drug effects,  physiology
Lung / growth & development,  physiology
Nerve Fibers, Unmyelinated / physiology
Pulmonary Stretch Receptors / physiology
Reflex / drug effects,  physiology*
Respiratory Mechanics / drug effects,  physiology*
Sheep
Stimulation, Chemical
Tidal Volume / drug effects,  physiology
Vagus Nerve / drug effects,  growth & development*,  physiology*
Chemical
Reg. No./Substance:
404-86-4/Capsaicin

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