| Postnatal maturation of vagal respiratory reflexes in preterm and full-term lambs. | |
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MedLine Citation:
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PMID: 12547837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The postnatal development of ventilatory reflexes originating from bronchopulmonary receptors was assessed in preterm vs. full-term lambs. Ventilation and arterial pressure were repeatedly measured in 10 preterm (gestational age, 132 days) and 7 full-term lambs without sedation from day 1 to day 42. The Hering-Breuer inhibitory reflex (slowly adapting stretch receptors) was assessed by the increase in expiratory time during end-inspiratory occlusion. The pulmonary chemoreflex (C-fiber endings) was assessed by the initial apnea + bradycardia + systemic hypotension and the secondary tachypnea after capsaicin intravenous injection. Results show the following. 1) Premature birth did not modify the maturation of the Hering-Breuer reflex. 2) Whereas a classic pulmonary chemoreflex was observed in the very first hours of life in preterm lambs, the tachypneic component of this reflex was weaker than in full-term lambs on day 1. 3) Premature birth led to a reversed postnatal maturation of this tachypneic response (tendency to increase with postnatal age). Our findings suggest that premature birth in lambs modifies postnatal maturation of the pulmonary chemoreflex. |
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Authors:
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Julie Arsenault; Francois Moreau-Bussiere; Philippe Reix; Theophile Niyonsenga; Jean-Paul Praud |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2003-01-24 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 94 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-04-07 Completed Date: 2003-11-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1978-86 Citation Subset: IM |
Affiliation:
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Respiratory Research Unit, Department of Public Health, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4, USA. Jp.Praud@USherbrooke.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology Animals Animals, Newborn / physiology* Blood Gas Analysis Blood Pressure / drug effects, physiology Capsaicin / pharmacology Heart Rate / drug effects, physiology Lung / growth & development, physiology Nerve Fibers, Unmyelinated / physiology Pulmonary Stretch Receptors / physiology Reflex / drug effects, physiology* Respiratory Mechanics / drug effects, physiology* Sheep Stimulation, Chemical Tidal Volume / drug effects, physiology Vagus Nerve / drug effects, growth & development*, physiology* |
| Chemical | |
Reg. No./Substance:
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404-86-4/Capsaicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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