Document Detail

Postnatal malnutrition and growth retardation: an inevitable consequence of current recommendations in preterm infants?
MedLine Citation:
PMID:  11158457     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Nutrient intakes meeting recommended dietary intakes (RDIs) take time to establish and once established are rarely maintained throughout hospital stay in preterm infants. A nutrient deficit, therefore, accrues. RDI are based on needs for maintenance and growth, with no provision to replace this deficit. We, therefore, hypothesized that postnatal malnutrition and growth retardation were inevitable in infants fed current RDI. METHODOLOGY: Dietary intakes were prospectively collected, by a single observer (N.P.), on a daily basis in a group of preterm infants (n = 105; birth weight </=1750 g; gestational age </=34 weeks) admitted to neonatal intensive care unit over a 6-month period. Actual was subtracted from recommended energy (120 kcal/kg/day) and protein (3 g/kg/day) intakes and nutritional deficits calculated. Infants were weighed on admission and throughout hospital stay. The data were analyzed using a combination of repeated measures analysis of variance and stepwise regression analysis. RESULTS: Nutrient intakes meeting current RDIs were rarely achieved during early life. By the end of the first week, cumulative energy and protein deficits were 406 +/- 92 and 335 +/- 86 kcal/kg and 14 +/- 3 and 12 +/- 4 g/kg in infants </=30 and those at >/=31 weeks. By the end of the fifth week, cumulative energy and protein deficits were 813 +/- 542 and 382 +/- 263 kcal/kg and 23 +/- 12 and 13 +/- 15 g/kg and the z scores were -1.14 +/-.6 and -.82 +/-.5 for infants at </=30 and >/=31 weeks. Stepwise regression analysis indicated that variation in dietary intake accounted for 45% of the variation in changes in z score. CONCLUSIONS: Preterm infants inevitably accumulate a significant nutrient deficit in the first few weeks of life that will not be replaced when current RDIs are fed. This deficit can be directly related to subsequent postnatal growth retardation.postnatal growth retardation, preterm infants.
N E Embleton; N Pang; R J Cooke
Related Documents :
3055997 - Ultrasonic growth parameters in fetuses of mothers with primary addiction to cocaine.
2380847 - Growth outcome and feeding practices of the very low birth weight infant (less than 150...
16675437 - Prenatal exposure to polychlorinated biphenyls and postnatal growth: a structural analy...
19159957 - Growth hormone treatment started in the first year of life in infants with chronic rena...
1452257 - Hepatitis b virus infection in pregnant mothers and its transmission to infants.
12199507 - Comparative studies of female sex pheromone components and male response of the corn st...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  107     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-05-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  270-3     Citation Subset:  IM    
Special Care Baby Unit, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analysis of Variance
Dietary Proteins / administration & dosage
Energy Intake
Enteral Nutrition
Food, Fortified
Gestational Age
Growth Disorders / etiology
Infant Food
Infant Nutritional Physiological Phenomena*
Infant, Newborn
Infant, Premature*
Milk, Human
Nutrition Disorders / etiology
Nutrition Policy*
Parenteral Nutrition, Total
Prospective Studies
Reg. No./Substance:
0/Dietary Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Prospective study of children with cyanotic and pallid breath-holding spells.
Next Document:  Early diagnosis of cystic fibrosis in the newborn period and risk of Pseudomonas aeruginosa acquisit...