Document Detail


Postnatal lead effects on the development of visual spatial acuity in rhesus monkeys (Macaca Mulatta).
MedLine Citation:
PMID:  18683184     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
High lead levels adversely affect visual function in humans and laboratory animals. The effects of lower lead levels are less certain. This study compared the development of photopic spatial acuity in rhesus monkeys exposed to lead (n = 43) with monkeys (n = 23) not exposed to lead. Lead exposure began at Day 8 postpartum and continued daily throughout the first 26 weeks of postnatal life achieving target blood lead levels of 35-40 microg/dl by about 15 weeks. Photopic spatial acuity was evaluated by a preferential looking technique used clinically to assess spatial acuity in human infants. Acuity increased rapidly over the first few postnatal weeks achieving the maximum acuity level assessed (26.3 c/deg) by 7 weeks of age for most monkeys. Postnatal lead exposure at the dosages and durations studied did not affect the development of photopic spatial acuity.
Authors:
Nellie K Laughlin; Melissa L Luck; Robert E Lasky
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Developmental psychobiology     Volume:  50     ISSN:  1098-2302     ISO Abbreviation:  Dev Psychobiol     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-15     Completed Date:  2009-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  608-14     Citation Subset:  IM    
Copyright Information:
(c) 2008 Wiley Periodicals, Inc.
Affiliation:
Harlow Center for Biological Psychology, The University of Wisconsin-Madison, Madison, WI 53715, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Female
Haplorhini
Lead / administration & dosage,  blood,  toxicity*
Lead Poisoning / blood*,  complications*
Macaca mulatta
Time Factors
Vision Disorders / etiology
Visual Acuity / drug effects*
Grant Support
ID/Acronym/Agency:
R01 ES06918/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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