| Postnatal intracerebroventricular exposure to neuropeptide Y causes weight loss in female adult rats. | |
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MedLine Citation:
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PMID: 12573978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the effect of repetitive postnatal (2-7 days) intracerebroventricular administration of neuropeptide Y (NPY) on food intake and body weight gain in the 3- to 120-day-old Sprague-Dawley rats. NPY caused a 32% transient increase in body weight gain with elevated circulating insulin concentrations within 24 h. This early intervention led to the persistence of hyperinsulinemia and relative hyperleptinemia with euglycemia in the 120-day-old female alone. This perturbation was associated with 50% suppression in adult female hypothalamic NPY concentrations and a 50-85% decline in NPY immunoreactivity in the paraventricular and arcuate nuclei. This change was paralleled by a approximately 20% decline in food intake and body weight gain at 60 and 120 days. However, when exogenous NPY was stereotaxically reinjected into the paraventricular nucleus of the approximately 120-day-old adult females who were pretreated with NPY postnatally, an increase in food intake and body weight gain was noted, attesting to no disruption in the NPY end-organ responsivity. We conclude that postnatal intracerebroventricular NPY has long-lasting effects that predetermine the resultant adult phenotype in a sex-specific manner. |
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Authors:
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Amit Varma; Jing He; Lisa Weissfeld; Sherin U Devaskar |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2003-02-06 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 284 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-05-08 Completed Date: 2003-06-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R1560-6 Citation Subset: IM |
Affiliation:
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University of Pittsburgh Schools of Medicine; Public Health, Pittsburgh, Pennsylvania 15213-3180, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Animals, Newborn Blood Glucose / analysis Feeding Behavior / drug effects Female Hypothalamus / drug effects, metabolism Immunohistochemistry Injections, Intraventricular Insulin / blood Leptin / blood Luteinizing Hormone / blood Male Neuropeptide Y / administration & dosage*, pharmacology* Organ Size Pregnancy Rats Rats, Sprague-Dawley Sex Characteristics Time Factors Weight Loss / drug effects*, physiology |
| Grant Support | |
ID/Acronym/Agency:
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HD-25024/HD/NICHD NIH HHS; HD-33997/HD/NICHD NIH HHS; HD-42130/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Leptin; 0/Neuropeptide Y; 11061-68-0/Insulin; 9002-67-9/Luteinizing Hormone |
| Comments/Corrections | |
Comment In:
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Am J Physiol Regul Integr Comp Physiol. 2003 Jun;284(6):R1382-3
[PMID:
12736174
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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