Document Detail

Postnatal intracerebroventricular exposure to neuropeptide Y causes weight loss in female adult rats.
MedLine Citation:
PMID:  12573978     Owner:  NLM     Status:  MEDLINE    
We investigated the effect of repetitive postnatal (2-7 days) intracerebroventricular administration of neuropeptide Y (NPY) on food intake and body weight gain in the 3- to 120-day-old Sprague-Dawley rats. NPY caused a 32% transient increase in body weight gain with elevated circulating insulin concentrations within 24 h. This early intervention led to the persistence of hyperinsulinemia and relative hyperleptinemia with euglycemia in the 120-day-old female alone. This perturbation was associated with 50% suppression in adult female hypothalamic NPY concentrations and a 50-85% decline in NPY immunoreactivity in the paraventricular and arcuate nuclei. This change was paralleled by a approximately 20% decline in food intake and body weight gain at 60 and 120 days. However, when exogenous NPY was stereotaxically reinjected into the paraventricular nucleus of the approximately 120-day-old adult females who were pretreated with NPY postnatally, an increase in food intake and body weight gain was noted, attesting to no disruption in the NPY end-organ responsivity. We conclude that postnatal intracerebroventricular NPY has long-lasting effects that predetermine the resultant adult phenotype in a sex-specific manner.
Amit Varma; Jing He; Lisa Weissfeld; Sherin U Devaskar
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2003-02-06
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  284     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-08     Completed Date:  2003-06-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1560-6     Citation Subset:  IM    
University of Pittsburgh Schools of Medicine; Public Health, Pittsburgh, Pennsylvania 15213-3180, USA.
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MeSH Terms
Aging / physiology*
Animals, Newborn
Blood Glucose / analysis
Feeding Behavior / drug effects
Hypothalamus / drug effects,  metabolism
Injections, Intraventricular
Insulin / blood
Leptin / blood
Luteinizing Hormone / blood
Neuropeptide Y / administration & dosage*,  pharmacology*
Organ Size
Rats, Sprague-Dawley
Sex Characteristics
Time Factors
Weight Loss / drug effects*,  physiology
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Leptin; 0/Neuropeptide Y; 11061-68-0/Insulin; 9002-67-9/Luteinizing Hormone
Comment In:
Am J Physiol Regul Integr Comp Physiol. 2003 Jun;284(6):R1382-3   [PMID:  12736174 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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