| Postnatal growth in a mouse genetic model of classical phenylketonuria. | |
| | |
MedLine Citation:
|
PMID: 11487255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Because of the ethical problems of withholding dietary treatment from patients with phenylketonuria, effectively studying long-term effects such as postnatal growth rates is difficult or impossible. The only literature available on the growth rate of phenylketonurics dates from the era before effective dietary treatment regimens were instituted routinely. Although some of these studies suggest that these patients have a reduced growth rate, whether this is a consistent feature of the untreated phenylketonuric is unclear. The mutant mouse line BTBR-Pahenu, a genetic model for human phenylketonuria, provides an opportunity to conduct studies that will clarify this issue. In this study, the weights of newborn mice were monitored from about 7 to 40 days after birth. Comparison to heterozygous, sex-matched littermates revealed a reduction in the size of homozygous mutants throughout the study. Therefore, reduced postnatal growth is an abiding feature of phenylketonuria in this mouse model. This finding not only helps to document the association between size reduction and untreated phenylketonuria but also sets the stage for studies designed to investigate the means by which size reduction occurs. |
| | |
Authors:
|
J D McDonald |
Related Documents
:
|
9508015 - The ketogenic diet: a practical guide for caregivers. 7492155 - Controlled trial of a few foods diet in severe atopic dermatitis. 17397265 - Natural approaches to epilepsy. 3780905 - Control of scar formation in experimentally induced epilepsy. 19457035 - The influence of urea feeding on the bacterial and archaeal community in the forestomac... 15591225 - Differential effect of experimental hypertension and hypercholesterolemia on adventitia... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science Volume: 39 ISSN: 1060-0558 ISO Abbreviation: Contemp Top Lab Anim Sci Publication Date: 2000 Nov |
Date Detail:
|
Created Date: 2001-08-06 Completed Date: 2001-08-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9204153 Medline TA: Contemp Top Lab Anim Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 54-6 Citation Subset: IM |
Affiliation:
|
Department of Biological Sciences, Wichita State University, 1845 Fairmount, Box 26, Wichita, KS 67260-0026, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Constitution Disease Models, Animal Female Growth* Male Mice / growth & development Phenylketonurias / complications*, genetics* Point Mutation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Improving the environment of mice by using synthetic gauze pads.
Next Document: Cholesterol granulomas in mice deficient in apolipoprotein E.