Document Detail

Postnatal growth failure in preterm infants: ascertainment and relation to long-term outcome.
MedLine Citation:
PMID:  17140299     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Traditional measure of postnatal growth failure assessment has poor discriminatory power for long-term outcomes. Our objective was to identify measure of postnatal growth failure associated with long-term outcome in preterm infants born at < 28 weeks' gestation. PATIENTS AND METHODS: Four measures of defining postnatal growth failure at 36 weeks corrected gestational age: (1) weight < 10(th) centile, (2) weight < 3(rd) centile, (3) z score difference from birth > 1 and, (4) z score difference from birth > 2; were compared for their predictive values and strength of association with adverse neurodevelopmental outcomes at 18-24 months. RESULTS: Postnatal growth failure defined as a decrease in z score of > 2 between birth and 36 weeks corrected gestational age had the best predictive values compared to other postnatal growth failure measures, however, it was significantly associated with psychomotor developmental (P=0.006) but not with mental developmental indices (P=0.379). CONCLUSION: Postnatal growth failure defined by z score change influenced psychomotor but not mental tasks in this cohort. This method of ascertainment could be useful to identify infants who might benefit from nutritional interventions.
Prakesh S Shah; Kit Y Wong; Susan Merko; Roshine Bishara; Michael Dunn; Elizabeth Asztalos; Pauline B Darling
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  34     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2006  
Date Detail:
Created Date:  2006-12-04     Completed Date:  2007-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  484-9     Citation Subset:  IM    
Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
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MeSH Terms
Gestational Age
Growth Disorders / diagnosis*
Infant Mortality
Infant, Newborn
Infant, Premature / growth & development*
Retrospective Studies

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