Document Detail


Postnatal growth deficits in prenatal ethanol-exposed mice: characteristics and critical periods.
MedLine Citation:
PMID:  1789388     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We previously reported that offspring of C57BL/6 mice maintained on liquid diets containing 20% or 25% ethanol-derived calories throughout pregnancy had birth weights comparable with controls but had weight reductions that became manifest around 23 to 28 days postnatally. Since this pattern of weight reduction may represent an unrecognized condition for human ethanol exposure, we completed a number of experiments to more thoroughly characterize the altered growth of prenatal ethanol exposed C57BL/6 mice. The results of this study indicate that consumption of liquid diets containing either 17% or 25% ethanol-derived calories during pregnancy can reduce growth of male and female offspring. Although attenuated postnatal growth of prenatal ethanol-exposed rodents is not commonly reported, prospective studies in humans suggest that in addition to having lower birth weights, children prenatally exposed to ethanol are postnatally growth retarded. Mice exposed to the low ethanol doses used in the present study had normal birth weights; however, their growth was attenuated between 19 and 28 days of age (preadolescent growth spurt) resulting in a weight reduction for at least 35 days, and which according to our previous report could extend into adulthood. The latter stages of gestation appear to be more sensitive to the postnatal growth retarding effect of prenatal ethanol exposure than early gestation. Caloric deficiency and postnatal maternal factors were eliminated as possible mechanisms for the growth deficit.
Authors:
L D Middaugh; W O Boggan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  15     ISSN:  0145-6008     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-03-20     Completed Date:  1992-03-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  919-26     Citation Subset:  IM    
Affiliation:
Medical University of South Carolina, Department of Psychiary and Behavioral Sciences, Charleston 29425-0742.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects*,  physiology
Dose-Response Relationship, Drug
Energy Intake / physiology
Ethanol / pharmacokinetics,  toxicity*
Female
Fetal Alcohol Syndrome / physiopathology*
Fetal Growth Retardation / physiopathology
Gestational Age
Mice
Mice, Inbred C57BL
Pregnancy
Grant Support
ID/Acronym/Agency:
AA06611/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
64-17-5/Ethanol
Comments/Corrections
Comment In:
Alcohol Clin Exp Res. 1991 Dec;15(6):903-4   [PMID:  1789385 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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