Document Detail

Postnatal glucocorticoid therapy for prevention of bronchopulmonary dysplasia: routes of administration compared.
MedLine Citation:
PMID:  11972435     Owner:  NLM     Status:  MEDLINE    
Postnatal systemic and inhaled glucocorticoid therapies continue to be used in the management of bronchopulmonary dysplasia (BPD). Systemic dexamethasone therapy has been studied longer than aerosolized glucocorticoid therapy. Several prophylactic trials of systemic dexamethasone therapy demonstrated a reduction in the incidence of BPD and neonatal mortality. However, evidence of potentially serious acute and long-term adverse effects has reduced enthusiasm for use of systemic dexamethasone therapy. Although no trial to date of inhaled glucocorticoid therapy showed a reduction in the incidence of BPD, some studies demonstrated secondary pulmonary benefits with few short-term adverse effects. This article compares the clinical efficacy and safety of these two routes of administration of glucocorticoid therapy.
C H Cole
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Seminars in neonatology : SN     Volume:  6     ISSN:  1084-2756     ISO Abbreviation:  Semin Neonatol     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2002-04-25     Completed Date:  2002-07-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9606001     Medline TA:  Semin Neonatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  343-50     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Ltd.
Division of Newborn Medicine, New England Medical Center, Tufts University School of Medicine, Boston, MA, USA.
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MeSH Terms
Administration, Inhalation
Bronchopulmonary Dysplasia / prevention & control*
Dexamethasone / administration & dosage
Glucocorticoids / administration & dosage*
Infant, Newborn
Infusions, Intravenous
Meta-Analysis as Topic
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Glucocorticoids; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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