| Postnatal glucocorticoid therapy for prevention of bronchopulmonary dysplasia: routes of administration compared. | |
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MedLine Citation:
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PMID: 11972435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postnatal systemic and inhaled glucocorticoid therapies continue to be used in the management of bronchopulmonary dysplasia (BPD). Systemic dexamethasone therapy has been studied longer than aerosolized glucocorticoid therapy. Several prophylactic trials of systemic dexamethasone therapy demonstrated a reduction in the incidence of BPD and neonatal mortality. However, evidence of potentially serious acute and long-term adverse effects has reduced enthusiasm for use of systemic dexamethasone therapy. Although no trial to date of inhaled glucocorticoid therapy showed a reduction in the incidence of BPD, some studies demonstrated secondary pulmonary benefits with few short-term adverse effects. This article compares the clinical efficacy and safety of these two routes of administration of glucocorticoid therapy. |
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Authors:
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C H Cole |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Seminars in neonatology : SN Volume: 6 ISSN: 1084-2756 ISO Abbreviation: Semin Neonatol Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2002-04-25 Completed Date: 2002-07-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9606001 Medline TA: Semin Neonatol Country: England |
Other Details:
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Languages: eng Pagination: 343-50 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Elsevier Science Ltd. |
Affiliation:
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Division of Newborn Medicine, New England Medical Center, Tufts University School of Medicine, Boston, MA, USA. ccole@lifespan.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Bronchopulmonary Dysplasia / prevention & control* Dexamethasone / administration & dosage Glucocorticoids / administration & dosage* Humans Infant, Newborn Infusions, Intravenous Meta-Analysis as Topic Randomized Controlled Trials as Topic |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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