Document Detail


Postnatal gender-dependent maturation of cellular cysteine uptake.
MedLine Citation:
PMID:  12420738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In view of the functional capacity of glutathione synthesis in premature infants, and because the availability of cysteine is one the rate limiting steps in glutathione synthesis, we hypothesized that the low glutathione levels in premature infants may be due to immaturity of the active cellular uptake of cysteine. OBJECTIVE: To document in cells from newborn infants the effect of maturity and gender on cysteine uptake and consequently on glutathione levels. METHODS: Incorporation of L-[35S] cysteine was measured in leukocytes from cord blood and from tracheal aspirates (TAC) of newborn infants of varying (gestational as well as postnatal) ages and gender. Cysteine uptake was correlated with glutathione in TAC. RESULTS: The maturity of newborn girls positively influences cysteine uptake, which is responsible for 78% of the variation in their glutathione content. However, in newborn boys, gestational and postnatal ages did not influence the cysteine uptake. DISCUSSION: Cysteine uptake appears to be the limiting step explaining the reported gender-related differences in glutathione as well as the low levels of this central antioxidant found in premature infants. The immature cysteine uptake found in cells from premature infants raises questions about the bioavailability of this conditionally essential amino acid in regimens of parenteral nutrition for human neonates.
Authors:
Jean-Claude Lavoie; Thérèse Rouleau; Anita C Truttmann; Philippe Chessex
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Free radical research     Volume:  36     ISSN:  1071-5762     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-11-07     Completed Date:  2003-04-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  811-7     Citation Subset:  IM    
Affiliation:
Research Centre and Neonatal Service, Hĵpital Ste-Justine, Montreal, Que, Canada. jclavoie@justine.umontreal.ca
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Antioxidants / metabolism
Cysteine / metabolism*,  pharmacokinetics*
Female
Fetal Blood / metabolism
Gestational Age
Glutathione / metabolism
Humans
Infant, Newborn
Infant, Premature
Male
Sex Factors
Time Factors
Trachea / metabolism
Chemical
Reg. No./Substance:
0/Antioxidants; 52-90-4/Cysteine; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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