Document Detail

Postnatal exposure to voluntary exercise but not the antioxidant catechin protects the vasculature after a switch to an atherogenic environment in middle-age mice.
MedLine Citation:
PMID:  23291710     Owner:  NLM     Status:  MEDLINE    
We aimed to evaluate the lasting functional imprinting of exercise (EX) and catechin (CAT) on the vascular function of middle-age mice switched to a proatherogenic environment. C57BL/6J mice (n = 10-15 in each group) fed a regular diet (RD) were exposed from the age of 1 to 9 months either to EX (voluntary running; 2.7 ± 0.2 km/day), to the polyphenol CAT (30 mg/kg/day in drinking water), or to physical inactivity (PI). At 9 months of age, EX and CAT were stopped and mice either remained on the RD or were fed a Western diet (WD) for an additional 3 months. At 12 months of age, mice from all groups fed a WD had similar body mass, systolic blood pressure, and plasma total cholesterol, glucose, insulin, and isoprostane. Compared to the RD, the WD induced an indomethacin-sensitive aortic endothelium-dependent and independent dysfunction in PI mice (p < 0.05) that was prevented by both EX and CAT; this benefit was associated with a higher (p < 0.05) non-nitric oxide/non-prostacyclin endothelium-dependent relaxation. While EX, but not PI or CAT, prevented vascular dysfunction induced by the WD in cerebral arteries, it had no effect in femoral arteries. The profiles of activity of antioxidant enzymes and of proinflammatory gene expression in the aorta suggest a better adaptation of EX > CAT > PI mice to stress. In conclusion, our data suggest that a postnatal exposure to EX, but not to CAT, imprints an adaptive defense capacity in the vasculature against a deleterious change in lifestyle.
Francois Leblond; Albert Nguyen; Virginie Bolduc; Jean Lambert; Carol Yu; Natacha Duquette; Eric Thorin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-06
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  465     ISSN:  1432-2013     ISO Abbreviation:  Pflugers Arch.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-01     Completed Date:  2013-07-17     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  197-208     Citation Subset:  IM    
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MeSH Terms
Age Factors
Antioxidants / pharmacology*
Arteries / metabolism,  physiology*
Atherosclerosis / prevention & control
Blood Glucose
Blood Pressure
Body Weight
Catechin / pharmacology*
Cholesterol / blood
Diet, Atherogenic
Endothelium, Vascular / metabolism,  physiology*
Insulin / blood
Isoprostanes / blood
Mice, Inbred C57BL
Physical Exertion*
Grant Support
14496-4//Canadian Institutes of Health Research; MOP#14496//Canadian Institutes of Health Research
Reg. No./Substance:
0/Antioxidants; 0/Blood Glucose; 0/Insulin; 0/Isoprostanes; 8R1V1STN48/Catechin; 97C5T2UQ7J/Cholesterol

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