Document Detail


Postnatal effects of oral administration of ethylenethiourea to rats during late pregnancy.
MedLine Citation:
PMID:  6933919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ethylenethiourea (ETU), a manufacturing, processing, and metabolic product of the ethylenebisdithiocarbamate fungicides, was evaluated for its effects on postnatal performance of rats. ETU was given to pregnant rats as a single oral dose of 1-50 mg/kg on day 17, 18, 19, or 20 of gestation. The number of stillborn rats was significantly increased at dose levels of 30 and 50 mg/kg. Treatment of dams with 50 mg/kg on day 20 of gestation caused reduction in the birth weight of the offspring. Progeny survival was impaired after maternal treatment with doses of 10 mg/kg and more. The high mortality was attributable to the development of hydrocephalus in the pups. At 6 months of age, 16 and 26% of the surviving offspring from dams treated with 10 or 20 mg/kg had hydrocephalus.
Authors:
H J Lewerenz; D W Bleyl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement     Volume:  4     ISSN:  0171-9750     ISO Abbreviation:  Arch. Toxicol. Suppl.     Publication Date:  1980  
Date Detail:
Created Date:  1981-01-29     Completed Date:  1981-01-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7802567     Medline TA:  Arch Toxicol Suppl     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  292-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Ethylenethiourea / toxicity*
Female
Fetal Death / chemically induced
Gestational Age
Growth / drug effects
Hydrocephalus / chemically induced
Imidazoles / toxicity*
Male
Pregnancy
Rats
Chemical
Reg. No./Substance:
0/Imidazoles; 96-45-7/Ethylenethiourea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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