Document Detail

Postnatal effects of oral administration of ethylenethiourea to rats during late pregnancy.
MedLine Citation:
PMID:  6933919     Owner:  NLM     Status:  MEDLINE    
Ethylenethiourea (ETU), a manufacturing, processing, and metabolic product of the ethylenebisdithiocarbamate fungicides, was evaluated for its effects on postnatal performance of rats. ETU was given to pregnant rats as a single oral dose of 1-50 mg/kg on day 17, 18, 19, or 20 of gestation. The number of stillborn rats was significantly increased at dose levels of 30 and 50 mg/kg. Treatment of dams with 50 mg/kg on day 20 of gestation caused reduction in the birth weight of the offspring. Progeny survival was impaired after maternal treatment with doses of 10 mg/kg and more. The high mortality was attributable to the development of hydrocephalus in the pups. At 6 months of age, 16 and 26% of the surviving offspring from dams treated with 10 or 20 mg/kg had hydrocephalus.
H J Lewerenz; D W Bleyl
Related Documents :
9628549 - The selective estrogen receptor modulator, raloxifene: reproductive assessments followi...
1593479 - Liquid flow across the epithelium of the artificially perfused lung of fetal and postna...
2274889 - Developmental toxicity of temafloxacin hydrochloride in the long-tailed macaque (macaca...
12530789 - Optimal designs for estimating the effective dose in developmental toxicity experiments.
3174289 - Effects of prenatal dexamethasone on development of ornithine decarboxylase activity in...
11943509 - Effects of prenatal exposure to manganese on postnatal development and behavior in mice...
16518709 - The integrated use of pharmacokinetic and pharmacodynamic models for the definition of ...
1277729 - Influence of acute viral hepatitis on disposition and pharmacologic effect of warfarin.
9492719 - Methylergometrine during the early puerperium; a prospective randomized double blind st...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement     Volume:  4     ISSN:  0171-9750     ISO Abbreviation:  Arch. Toxicol. Suppl.     Publication Date:  1980  
Date Detail:
Created Date:  1981-01-29     Completed Date:  1981-01-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7802567     Medline TA:  Arch Toxicol Suppl     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  292-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Oral
Ethylenethiourea / toxicity*
Fetal Death / chemically induced
Gestational Age
Growth / drug effects
Hydrocephalus / chemically induced
Imidazoles / toxicity*
Reg. No./Substance:
0/Imidazoles; 96-45-7/Ethylenethiourea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Experiences with a three step test scheme for embryotoxicity and teratogenicity.
Next Document:  Activity of some mixed function oxidases in prenatally carbon disulphide (CS2) treated rats.