Document Detail


Postnatal development of nutrient transport in the intestine of dogs.
MedLine Citation:
PMID:  12755305     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To measure nutrient absorption by the intestine during postnatal development of dogs. ANIMAL: 110 Beagles ranging from neonatal to adult dogs. PROCEDURE: Rates of absorption for sugars (glucose, galactose, and fructose), amino acids (aspartate, leucine, lysine, methionine, and proline), a dipeptide (glycyl-sarcosine), and linoleic acid by the proximal, mid, and distal regions of the small intestine were measured as functions of age and concentration (kinetics) by use of intact tissues and brush-border membrane vesicles. Absorption of octanoic acid by the proximal portion of the colon was measured in intact tissues. RESULTS: Rates of carrier-mediated transport by intact tissues decreased from birth to adulthood for aldohexoses and most amino acids but not for fructose and aspartate. Kinetics and characteristics of absorption suggest that there were changes in the densities, types, and proportions of various carriers for sugars and amino acids. Saturable absorption of linoleic acid in the small intestine and octanoic acid in the proximal portion of the colon increased after weaning. CONCLUSIONS AND CLINICAL RELEVANCE: Rates of absorption decreased between birth and adulthood for most nutrients. However, because of intestinal growth, absorption capacities of the entire small intestine remained constant for leucine and proline and increased for glucose, galactose, fructose, aspartate, and proline but were less than predicted from the increase in body weight. Although postnatal ontogeny of nutrient absorption was consistent with changes in the composition of the natural and commercial diets of growing dogs, rates of amino acid and peptide absorption were lower than expected.
Authors:
Randal K Buddington; Christiane Malo
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  64     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-20     Completed Date:  2003-07-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  635-45     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, College of Arts and Science, Mississippi State University, Mississippi State, MS 39762, USA.
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MeSH Terms
Descriptor/Qualifier:
Absorption
Aging / physiology*
Amino Acids / metabolism
Animals
Animals, Newborn
Animals, Suckling
Biological Transport
Carbohydrate Metabolism
Dipeptides / metabolism
Dogs / growth & development*,  metabolism*
Female
Intestinal Mucosa / growth & development,  metabolism
Intestine, Small / growth & development*,  metabolism*
Kinetics
Linoleic Acid / metabolism
Male
Microvilli / metabolism
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Dipeptides; 2197-37-7/Linoleic Acid; 29816-01-1/glycylsarcosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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