Document Detail


Postnatal development of the mucosal plexus in the porcine small and large intestine.
MedLine Citation:
PMID:  17006708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Knowledge regarding the foetal and postnatal development of the enteric nervous system is crucial for the understanding of congenital disorders. While lot of information exists regarding the myenteric and submucosal plexuses, the development of the mucosal plexus has not been previously studied. The mucosal innervation seems to play an important role in the local reflex activity of the gut. In this study, we examined the development of enteric mucosal innervation in the pig at various ages of life. Small and large bowel paraffin-embedded specimens were stained with PGP 9.5 and neurofilament protein in three piglets from six age groups (60 and 90 days gestation, newborn, 4 and 12 weeks old, and adult pigs). Small and large bowel demonstrated identical innervation patterns. Myenteric and submucosal plexuses were stained with PGP 9.5 at 60 days gestation. However, the mucosal staining was first noted clearly at the newborn period. By 4 weeks, PGP 9.5 staining was noted in small amounts within the mucosa. Inner proprial and villous fibres were seen ahead in time to the subepithelial fibres. Both inner proprial and villous staining became quiet prominent by 12 weeks of age and remained unchanged into adulthood. However, the subepithelial fibres appear to increase in adulthood. This study demonstrates for the first time that enteric mucosal innervation first appears only at birth. The immaturity of the mucosa generated reflex activity, and secretory functions may have implication in the management of functional intestinal obstruction in the premature infant.
Authors:
Thambipillai Sri Paran; Udo Rolle; Prem Puri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric surgery international     Volume:  22     ISSN:  0179-0358     ISO Abbreviation:  Pediatr. Surg. Int.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-22     Completed Date:  2007-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8609169     Medline TA:  Pediatr Surg Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  997-1001     Citation Subset:  IM    
Affiliation:
Children's Research Centre, Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Ganglia / growth & development
Immunohistochemistry
Intestinal Mucosa / growth & development*,  innervation,  metabolism,  physiopathology
Intestine, Large / growth & development,  innervation
Intestine, Small / growth & development,  innervation
Submucous Plexus / physiopathology*
Swine
Ubiquitin Thiolesterase / metabolism
Chemical
Reg. No./Substance:
EC 3.1.2.15/UCHL1 protein, human; EC 3.1.2.15/Ubiquitin Thiolesterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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