| Postnatal development of hypothalamic inputs to the dorsal vagal complex in rats. | |
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MedLine Citation:
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PMID: 12818710 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hypothalamus is critically involved in energy homeostasis and is an appropriate focus for research investigating the central neural underpinnings of obesity, anorexia and normal food intake. However, little is known regarding pathways and mechanisms that convey relevant hypothalamic signals to the brainstem circuits that ultimately control ingestive behavior. This brief review highlights work investigating the postnatal development of hypothalamic inputs to the hindbrain dorsal vagal complex (DVC). Research findings indicate that these inputs are both structurally and functionally immature in newborn rats. The progressive postnatal maturation of descending projections to the DVC occurs in concert with newly emerging physiological and behavioral responses to osmotic dehydration, which inhibits gastric emptying and food intake in adult animals but not in neonates. The postnatal emergence of other intake controls might also reflect progressive engagement of DVC neural circuits, whose intrinsic components and output pathways are envisioned as being critical for initiating and terminating ingestive behavior. |
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Authors:
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Linda Rinaman |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Physiology & behavior Volume: 79 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-23 Completed Date: 2004-01-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 65-70 Citation Subset: IM |
Affiliation:
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Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA. Rinaman@pitt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Animals, Newborn Appetite / physiology* Brain Mapping Drinking / physiology Feeding Behavior / physiology* Hypothalamus / anatomy & histology, physiology* Nodose Ganglion / anatomy & histology, physiology Rats Rhombencephalon / anatomy & histology, physiology Vagus Nerve / anatomy & histology, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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MH01208/MH/NIMH NIH HHS; MH59911/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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