Document Detail


Postnatal development of hypothalamic inputs to the dorsal vagal complex in rats.
MedLine Citation:
PMID:  12818710     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hypothalamus is critically involved in energy homeostasis and is an appropriate focus for research investigating the central neural underpinnings of obesity, anorexia and normal food intake. However, little is known regarding pathways and mechanisms that convey relevant hypothalamic signals to the brainstem circuits that ultimately control ingestive behavior. This brief review highlights work investigating the postnatal development of hypothalamic inputs to the hindbrain dorsal vagal complex (DVC). Research findings indicate that these inputs are both structurally and functionally immature in newborn rats. The progressive postnatal maturation of descending projections to the DVC occurs in concert with newly emerging physiological and behavioral responses to osmotic dehydration, which inhibits gastric emptying and food intake in adult animals but not in neonates. The postnatal emergence of other intake controls might also reflect progressive engagement of DVC neural circuits, whose intrinsic components and output pathways are envisioned as being critical for initiating and terminating ingestive behavior.
Authors:
Linda Rinaman
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  79     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-23     Completed Date:  2004-01-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  IM    
Affiliation:
Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA. Rinaman@pitt.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Animals, Newborn
Appetite / physiology*
Brain Mapping
Drinking / physiology
Feeding Behavior / physiology*
Hypothalamus / anatomy & histology,  physiology*
Nodose Ganglion / anatomy & histology,  physiology
Rats
Rhombencephalon / anatomy & histology,  physiology
Vagus Nerve / anatomy & histology,  physiology*
Grant Support
ID/Acronym/Agency:
MH01208/MH/NIMH NIH HHS; MH59911/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ontogeny of the hypothalamic neuropeptide Y system.
Next Document:  Do metabolic signals stimulate intake in rat pups?