Document Detail


Postnatal development of different classes of cat retinal ganglion cells.
MedLine Citation:
PMID:  8106655     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous investigators have documented the postnatal development of alpha and beta type ganglion cells in cat retinae (Ramoa et al. [1987] Science 237:522-525; Ramoa et al. [1988] J. Neurosci. 8:4239-4261; Dann et al. [1987] Neurosci. Lett. 80:21-26; Dann et al. [1988] J. Neurosci. 8(5):1485-1499). The development of the remaining cells (about 50%), which constitute a heterogeneous group and are referred to here collectively as gamma cells (Boycott and Wässle, '74), has not been studied in detail. The purpose of this study was to compare the postnatal development of alpha, beta, and gamma cells in kitten and adult retinae using horseradish peroxidase histochemistry and the fluorescent dye DiI. In the kitten, alpha, beta, and gamma cells are recognizable. We find, as have others, that kitten alpha and beta cell bodies and dendritic fields are significantly smaller than in the adult. However, kitten gamma cells are nearly adult sized. In fact, at birth the cell bodies of beta cells throughout the retina are significantly smaller than those of gamma cells. During the first 12 weeks of life, alpha and beta cell bodies increase in size from 90% to 680% depending upon eccentricity. Gamma cells hardly increase in size at all. Also, the normal adult center-to-peripheral cell size gradient for alpha and beta cells is not seen in the neonate. Gamma cells show no such gradient in the neonate or adult. Our results suggest that the morphological development of alpha and beta cells occurs later than that of gamma cells and may explain some of the differences in the effects of visual deprivation and surgical manipulation upon the parallel Y-, X-, and W-cell pathways.
Authors:
S J Ault; A G Leventhal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  339     ISSN:  0021-9967     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-03-24     Completed Date:  1994-03-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  106-16     Citation Subset:  IM    
Affiliation:
Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City 84132.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Carbocyanines
Cats
Dendrites / physiology,  ultrastructure
Geniculate Bodies / cytology,  physiology
Histocytochemistry
Horseradish Peroxidase
Retina / growth & development*
Retinal Ganglion Cells / physiology*
Superior Colliculi / cytology,  physiology
Chemical
Reg. No./Substance:
0/Carbocyanines; 40957-95-7/3,3'-dioctadecylindocarbocyanine; EC 1.11.1.-/Horseradish Peroxidase

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